BRD-K25737009_-666_PC3_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

249 genes differentially expressed following the BRD-K25737009_-666_PC3_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACBD3 acyl-CoA binding domain containing 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CARS cysteinyl-tRNA synthetase
CCNL1 cyclin L1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CLGN calmegin
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPAS1 endothelial PAS domain protein 1
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPM6B glycoprotein M6B
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IL6 interleukin 6
IQCG IQ motif containing G
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KAT6B K(lysine) acetyltransferase 6B
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT6B keratin 6B, type II
KRT81 keratin 81, type II
LARP6 La ribonucleoprotein domain family, member 6
LPAR2 lysophosphatidic acid receptor 2
MAL mal, T-cell differentiation protein
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MICALL1 MICAL-like 1
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIT1 nitrilase 1
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS2 protease, serine, 2 (trypsin 2)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB29 RAB29, member RAS oncogene family
RBKS ribokinase
RBM47 RNA binding motif protein 47
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIPK2 receptor-interacting serine-threonine kinase 2
RND1 Rho family GTPase 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCYL3 SCY1-like 3 (S. cerevisiae)
SIK3 SIK family kinase 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SRRM2 serine/arginine repetitive matrix 2
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TARS threonyl-tRNA synthetase
TFE3 transcription factor binding to IGHM enhancer 3
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTC1 actin, alpha, cardiac muscle 1
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
APMAP adipocyte plasma membrane associated protein
ARL5A ADP-ribosylation factor-like 5A
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
B3GNT1
BLCAP bladder cancer associated protein
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BZW1 basic leucine zipper and W2 domains 1
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV2 caveolin 2
CCL8 chemokine (C-C motif) ligand 8
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD164 CD164 molecule, sialomucin
CD46 CD46 molecule, complement regulatory protein
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFH complement factor H
CST7 cystatin F (leukocystatin)
CTSA cathepsin A
CTSH cathepsin H
CXCL11 chemokine (C-X-C motif) ligand 11
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DES desmin
DICER1 dicer 1, ribonuclease type III
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLG5 discs, large homolog 5 (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
DSCC1 DNA replication and sister chromatid cohesion 1
EID1 EP300 interacting inhibitor of differentiation 1
ENO1 enolase 1, (alpha)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FXYD3 FXYD domain containing ion transport regulator 3
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GLUL glutamate-ammonia ligase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GNS glucosamine (N-acetyl)-6-sulfatase
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HAT1 histone acetyltransferase 1
HOXA10 homeobox A10
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
KANK2 KN motif and ankyrin repeat domains 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT1 keratin 1, type II
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LAPTM4B lysosomal protein transmembrane 4 beta
LIPA lipase A, lysosomal acid, cholesterol esterase
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCAM melanoma cell adhesion molecule
MCM6 minichromosome maintenance complex component 6
MYH11 myosin, heavy chain 11, smooth muscle
NID1 nidogen 1
NPTN neuroplastin
NRN1 neuritin 1
OLFM1 olfactomedin 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PLBD1 phospholipase B domain containing 1
PLN phospholamban
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRDX1 peroxiredoxin 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RNF130 ring finger protein 130
RPA1 replication protein A1, 70kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SORD sorbitol dehydrogenase
SPTSSA serine palmitoyltransferase, small subunit A
STOM stomatin
TFRC transferrin receptor
TGM2 transglutaminase 2
TMPO thymopoietin
TSPAN12 tetraspanin 12
Funding