BRD-K25737009_-666_PL21_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K25737009_-666_PL21_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DOCK4 dedicator of cytokinesis 4
DUSP1 dual specificity phosphatase 1
EGLN3 egl-9 family hypoxia-inducible factor 3
FGFR2 fibroblast growth factor receptor 2
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GRB7 growth factor receptor-bound protein 7
H2BFS H2B histone family, member S (pseudogene)
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB6 homeobox B6
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IL1R2 interleukin 1 receptor, type II
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KIAA1598
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MEST mesoderm specific transcript
MRPL40 mitochondrial ribosomal protein L40
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NCF2 neutrophil cytosolic factor 2
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PON3 paraoxonase 3
PRAME preferentially expressed antigen in melanoma
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTBP2 polypyrimidine tract binding protein 2
PTPRO protein tyrosine phosphatase, receptor type, O
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RHOB ras homolog family member B
SARS seryl-tRNA synthetase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDF2L1 stromal cell-derived factor 2-like 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP29 synaptosomal-associated protein, 29kDa
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SQSTM1 sequestosome 1
TBC1D15 TBC1 domain family, member 15
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TWIST1 twist family bHLH transcription factor 1
UBE2B ubiquitin-conjugating enzyme E2B

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACLY ATP citrate lyase
AKAP8 A kinase (PRKA) anchor protein 8
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
BCL2 B-cell CLL/lymphoma 2
BST2 bone marrow stromal cell antigen 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL2 chemokine (C-C motif) ligand 2
CCNF cyclin F
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPF centromere protein F, 350/400kDa
CHD7 chromodomain helicase DNA binding protein 7
CPD carboxypeptidase D
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP7 dual specificity phosphatase 7
EBP emopamil binding protein (sterol isomerase)
EFNB2 ephrin-B2
EIF4A1 eukaryotic translation initiation factor 4A1
FAM111A family with sequence similarity 111, member A
FASTKD5 FAST kinase domains 5
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HMGB3 high mobility group box 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1L hematological and neurological expressed 1-like
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
IPO5 importin 5
KANK1 KN motif and ankyrin repeat domains 1
KANK2 KN motif and ankyrin repeat domains 2
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDHB lactate dehydrogenase B
LDLR low density lipoprotein receptor
LGMN legumain
LINC00341 long intergenic non-protein coding RNA 341
LMNB2 lamin B2
LPL lipoprotein lipase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
METRN meteorin, glial cell differentiation regulator
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYO6 myosin VI
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEFH neurofilament, heavy polypeptide
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NPY neuropeptide Y
NT5DC2 5'-nucleotidase domain containing 2
PARP1 poly (ADP-ribose) polymerase 1
PIH1D1 PIH1 domain containing 1
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PRDX1 peroxiredoxin 1
PXDN peroxidasin
RPA1 replication protein A1, 70kDa
RRP1B ribosomal RNA processing 1B
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SQLE squalene epoxidase
TARP TCR gamma alternate reading frame protein
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM2 translocation associated membrane protein 2
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE2C ubiquitin-conjugating enzyme E2C
UBE3C ubiquitin protein ligase E3C
URI1 URI1, prefoldin-like chaperone
VDAC1 voltage-dependent anion channel 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Funding