BRD-K25737009_-666_RKO_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K25737009_-666_RKO_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANPEP alanyl (membrane) aminopeptidase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
BAG3 BCL2-associated athanogene 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF54 chromosome 1 open reading frame 54
CA2 carbonic anhydrase II
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CRYAB crystallin, alpha B
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZR ezrin
FAIM Fas apoptotic inhibitory molecule
FAM107A family with sequence similarity 107, member A
FBXO11 F-box protein 11
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GJA1 gap junction protein, alpha 1, 43kDa
GPER1 G protein-coupled estrogen receptor 1
GREB1 growth regulation by estrogen in breast cancer 1
GSPT1 G1 to S phase transition 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HEPH hephaestin
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
JCHAIN joining chain of multimeric IgA and IgM
KHNYN KH and NYN domain containing
KIAA0430 KIAA0430
LAMP3 lysosomal-associated membrane protein 3
LITAF lipopolysaccharide-induced TNF factor
LRMP lymphoid-restricted membrane protein
MAN2A1 mannosidase, alpha, class 2A, member 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MBP myelin basic protein
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MSMB microseminoprotein, beta-
MT1M metallothionein 1M
NEFH neurofilament, heavy polypeptide
NGRN neugrin, neurite outgrowth associated
NUPR1 nuclear protein, transcriptional regulator, 1
PENK proenkephalin
PLA1A phospholipase A1 member A
PLP1 proteolipid protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPIC peptidylprolyl isomerase C (cyclophilin C)
RABGAP1L RAB GTPase activating protein 1-like
RGCC regulator of cell cycle
RGS13 regulator of G-protein signaling 13
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SELE selectin E
SELENBP1 selenium binding protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP1 secreted frizzled-related protein 1
SH3BGR SH3 domain binding glutamate-rich protein
SNN stannin
SOD2 superoxide dismutase 2, mitochondrial
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC2 stanniocalcin 2
TCL1A T-cell leukemia/lymphoma 1A
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TP53BP2 tumor protein p53 binding protein 2
TPM2 tropomyosin 2 (beta)
TTC39A tetratricopeptide repeat domain 39A
VEGFA vascular endothelial growth factor A
VGLL1 vestigial-like family member 1
VPREB3 pre-B lymphocyte 3
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1

decreased expression

Symbol Name
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANKRD10 ankyrin repeat domain 10
APMAP adipocyte plasma membrane associated protein
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLCAP bladder cancer associated protein
BMI1 BMI1 proto-oncogene, polycomb ring finger
CBR4 carbonyl reductase 4
CCNF cyclin F
CDA cytidine deaminase
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
COX11 COX11 cytochrome c oxidase copper chaperone
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EPN2 epsin 2
F12 coagulation factor XII (Hageman factor)
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GGCT gamma-glutamylcyclotransferase
GNAS GNAS complex locus
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
IL1RAP interleukin 1 receptor accessory protein
KDM5D lysine (K)-specific demethylase 5D
KRT10 keratin 10, type I
LAPTM4B lysosomal protein transmembrane 4 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS1 Meis homeobox 1
MGST2 microsomal glutathione S-transferase 2
MLEC malectin
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
NUAK1 NUAK family, SNF1-like kinase, 1
PBX3 pre-B-cell leukemia homeobox 3
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
REEP1 receptor accessory protein 1
RFK riboflavin kinase
RIN2 Ras and Rab interactor 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD5 stearoyl-CoA desaturase 5
SCML1 sex comb on midleg-like 1 (Drosophila)
SCML2 sex comb on midleg-like 2 (Drosophila)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHB Src homology 2 domain containing adaptor protein B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STX1A syntaxin 1A (brain)
TEX10 testis expressed 10
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TRIM14 tripartite motif containing 14
ZNF512B zinc finger protein 512B
Funding