BRD-K25737009_-666_SNGM_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K25737009_-666_SNGM_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
CD24 CD24 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CLDN7 claudin 7
CLIC3 chloride intracellular channel 3
CNN3 calponin 3, acidic
CRISP3 cysteine-rich secretory protein 3
CTBP2 C-terminal binding protein 2
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FOLR1 folate receptor 1 (adult)
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LCN2 lipocalin 2
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA4 melanoma antigen family A4
MAGEA5 melanoma antigen family A5
MAGEA6 melanoma antigen family A6
MAGEB2 melanoma antigen family B2
MXI1 MAX interactor 1, dimerization protein
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAM1 neural cell adhesion molecule 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAD23B RAD23 homolog B (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TP53BP2 tumor protein p53 binding protein 2
UPP1 uridine phosphorylase 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHR aryl hydrocarbon receptor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA4 annexin A4
APOC1 apolipoprotein C-I
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CALD1 caldesmon 1
CCND1 cyclin D1
CCND2 cyclin D2
CCNF cyclin F
CCNG1 cyclin G1
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5A cytochrome b5 type A (microsomal)
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
EIF5B eukaryotic translation initiation factor 5B
FABP7 fatty acid binding protein 7, brain
FAM57A family with sequence similarity 57, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLUL glutamate-ammonia ligase
GPC4 glypican 4
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
HOXA5 homeobox A5
HOXD1 homeobox D1
IDO1 indoleamine 2,3-dioxygenase 1
KCTD12 potassium channel tetramerization domain containing 12
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYPD1 LY6/PLAUR domain containing 1
MAGED1 melanoma antigen family D1
MET MET proto-oncogene, receptor tyrosine kinase
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
NUP62 nucleoporin 62kDa
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDGFA platelet-derived growth factor alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PRPS2 phosphoribosyl pyrophosphate synthetase 2
RAB4A RAB4A, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM47 RNA binding motif protein 47
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS1 regulator of G-protein signaling 1
RNASET2 ribonuclease T2
RPS11 ribosomal protein S11
RRP1B ribosomal RNA processing 1B
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
STARD7 StAR-related lipid transfer (START) domain containing 7
STK26 serine/threonine protein kinase 26
TBC1D16 TBC1 domain family, member 16
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN12 tetraspanin 12
TSPAN3 tetraspanin 3
TXNDC9 thioredoxin domain containing 9
VWA5A von Willebrand factor A domain containing 5A
Funding