BRD-K25737009_-666_SNUC4_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K25737009_-666_SNUC4_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANOS1 anosmin 1
ANXA3 annexin A3
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHIC2 cysteine-rich hydrophobic domain 2
CLGN calmegin
COL14A1 collagen, type XIV, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSTA cystatin A (stefin A)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYTH1 cytohesin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSC2 desmocollin 2
DSP desmoplakin
DST dystonin
EGFR epidermal growth factor receptor
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5A eukaryotic translation initiation factor 5A
EVI2B ecotropic viral integration site 2B
EXT1 exostosin glycosyltransferase 1
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HSPA13 heat shock protein 70kDa family, member 13
IGF1 insulin-like growth factor 1 (somatomedin C)
IRF8 interferon regulatory factor 8
ITGA6 integrin, alpha 6
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARS methionyl-tRNA synthetase
MTMR11 myotubularin related protein 11
MYO6 myosin VI
NEFL neurofilament, light polypeptide
NRGN neurogranin (protein kinase C substrate, RC3)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RIPK2 receptor-interacting serine-threonine kinase 2
RNF167 ring finger protein 167
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP4 secreted frizzled-related protein 4
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SST somatostatin
STAR steroidogenic acute regulatory protein
STX1A syntaxin 1A (brain)
SUCO SUN domain containing ossification factor
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TACSTD2 tumor-associated calcium signal transducer 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UBXN4 UBX domain protein 4
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
ZBTB43 zinc finger and BTB domain containing 43
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
AHCY adenosylhomocysteinase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMACR alpha-methylacyl-CoA racemase
APOD apolipoprotein D
B3GNT1
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CD59 CD59 molecule, complement regulatory protein
CLCA1 chloride channel accessory 1
COLEC12 collectin sub-family member 12
CTSB cathepsin B
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCT dopachrome tautomerase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
EPN2 epsin 2
ETV1 ets variant 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
GRWD1 glutamate-rich WD repeat containing 1
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
MUC4 mucin 4, cell surface associated
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
PDHX pyruvate dehydrogenase complex, component X
PMEL premelanosome protein
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RBPMS RNA binding protein with multiple splicing
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNX10 sorting nexin 10
SORBS1 sorbin and SH3 domain containing 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STOM stomatin
SUMO3 small ubiquitin-like modifier 3
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TNS3 tensin 3
TOX thymocyte selection-associated high mobility group box
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBB tubulin, beta class I
VGLL4 vestigial-like family member 4
Funding