BRD-K25737009_-666_SW480_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K25737009_-666_SW480_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ANPEP alanyl (membrane) aminopeptidase
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BID BH3 interacting domain death agonist
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CCNL1 cyclin L1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHN1 chimerin 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR3 early growth response 3
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KRT19 keratin 19, type I
L1CAM L1 cell adhesion molecule
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MSMB microseminoprotein, beta-
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHIP pleckstrin homology domain interacting protein
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMM2 phosphomannomutase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRO protein tyrosine phosphatase, receptor type, O
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
SCGB1D2 secretoglobin, family 1D, member 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
SST somatostatin
TDO2 tryptophan 2,3-dioxygenase
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ALOX5 arachidonate 5-lipoxygenase
ANO1 anoctamin 1, calcium activated chloride channel
APMAP adipocyte plasma membrane associated protein
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAV2 caveolin 2
CDA cytidine deaminase
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CRIP1 cysteine-rich protein 1 (intestinal)
CTSH cathepsin H
CTSS cathepsin S
DLD dihydrolipoamide dehydrogenase
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPN2 epsin 2
FBXO11 F-box protein 11
FLG filaggrin
FXYD2 FXYD domain containing ion transport regulator 2
GRN granulin
HDGFRP3 hepatoma-derived growth factor, related protein 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI30 interferon, gamma-inducible protein 30
IFITM1 interferon induced transmembrane protein 1
IGKV1-5 immunoglobulin kappa variable 1-5
ITGB1BP1 integrin beta 1 binding protein 1
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
KRT1 keratin 1, type II
LEPR leptin receptor
MARCKSL1 MARCKS-like 1
MEGF9 multiple EGF-like-domains 9
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PGAM1 phosphoglycerate mutase 1 (brain)
PIP prolactin-induced protein
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PSPH phosphoserine phosphatase
RABAC1 Rab acceptor 1 (prenylated)
RBP1 retinol binding protein 1, cellular
RPA3 replication protein A3, 14kDa
RTN3 reticulon 3
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SORBS3 sorbin and SH3 domain containing 3
SPP1 secreted phosphoprotein 1
SPRR1B small proline-rich protein 1B
SS18 synovial sarcoma translocation, chromosome 18
TCL1A T-cell leukemia/lymphoma 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TXNL4A thioredoxin-like 4A
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)
Funding