BRD-K25737009_-666_SW620_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-K25737009_-666_SW620_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANKRD10 ankyrin repeat domain 10
AQP1 aquaporin 1 (Colton blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BHLHE40 basic helix-loop-helix family, member e40
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CAV1 caveolin 1, caveolae protein, 22kDa
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CSRP1 cysteine and glycine-rich protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EZR ezrin
FAM129A family with sequence similarity 129, member A
FAM13A family with sequence similarity 13, member A
FILIP1L filamin A interacting protein 1-like
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GAREM GRB2 associated, regulator of MAPK1
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MT1G metallothionein 1G
MXI1 MAX interactor 1, dimerization protein
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRL platelet-derived growth factor receptor-like
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RND3 Rho family GTPase 3
RSRC2 arginine/serine-rich coiled-coil 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC38A2 solute carrier family 38, member 2
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGIF1 TGFB-induced factor homeobox 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPBG trophoblast glycoprotein
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VEGFA vascular endothelial growth factor A
WLS wntless Wnt ligand secretion mediator
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF331 zinc finger protein 331
ZNF394 zinc finger protein 394

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
APMAP adipocyte plasma membrane associated protein
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BLMH bleomycin hydrolase
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK4 cyclin-dependent kinase 4
CENPA centromere protein A
CST3 cystatin C
CTPS1 CTP synthase 1
CTSH cathepsin H
DKK1 dickkopf WNT signaling pathway inhibitor 1
FHL1 four and a half LIM domains 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
KAZN kazrin, periplakin interacting protein
KIF2C kinesin family member 2C
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED1 melanoma antigen family D1
MET MET proto-oncogene, receptor tyrosine kinase
MLEC malectin
MTDH metadherin
NPY neuropeptide Y
NT5DC2 5'-nucleotidase domain containing 2
NUP210 nucleoporin 210kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDGFA platelet-derived growth factor alpha polypeptide
PFN2 profilin 2
PLA1A phospholipase A1 member A
PLK1 polo-like kinase 1
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
RBP1 retinol binding protein 1, cellular
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPA1 replication protein A1, 70kDa
RPS11 ribosomal protein S11
RRP1B ribosomal RNA processing 1B
SACS sacsin molecular chaperone
SEPHS1 selenophosphate synthetase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SRSF1 serine/arginine-rich splicing factor 1
TBC1D4 TBC1 domain family, member 4
TM9SF2 transmembrane 9 superfamily member 2
TMX4 thioredoxin-related transmembrane protein 4
TOP2A topoisomerase (DNA) II alpha 170kDa
UGCG UDP-glucose ceramide glucosyltransferase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WSB2 WD repeat and SOCS box containing 2
Funding