BRD-K25737009_-666_SW948_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K25737009_-666_SW948_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL2 adhesion G protein-coupled receptor L2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BEX4 brain expressed, X-linked 4
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CD163 CD163 molecule
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CES1 carboxylesterase 1
CLDN10 claudin 10
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
FAM129A family with sequence similarity 129, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HCAR3 hydroxycarboxylic acid receptor 3
HIPK2 homeodomain interacting protein kinase 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
LGALS1 lectin, galactoside-binding, soluble, 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1G metallothionein 1G
MT1X metallothionein 1X
NBEA neurobeachin
NEB nebulin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
PER1 period circadian clock 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
PXDN peroxidasin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SRGN serglycin
SST somatostatin
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TMEM176A transmembrane protein 176A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53I3 tumor protein p53 inducible protein 3
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK1 adenylate kinase 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
APMAP adipocyte plasma membrane associated protein
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
C5ORF15 chromosome 5 open reading frame 15
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCDC47 coiled-coil domain containing 47
CD164 CD164 molecule, sialomucin
CD24 CD24 molecule
CD47 CD47 molecule
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
CTSB cathepsin B
CXCL14 chemokine (C-X-C motif) ligand 14
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCK deoxycytidine kinase
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
GNS glucosamine (N-acetyl)-6-sulfatase
GRB14 growth factor receptor-bound protein 14
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
HDAC1 histone deacetylase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HN1L hematological and neurological expressed 1-like
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IL13RA2 interleukin 13 receptor, alpha 2
KANK1 KN motif and ankyrin repeat domains 1
KLK10 kallikrein-related peptidase 10
LEPROTL1 leptin receptor overlapping transcript-like 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LYPLA1 lysophospholipase I
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MET MET proto-oncogene, receptor tyrosine kinase
MLEC malectin
MPZL1 myelin protein zero-like 1
MYCBP MYC binding protein
NADK NAD kinase
NAV2 neuron navigator 2
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
PDIA3 protein disulfide isomerase family A, member 3
PEBP1 phosphatidylethanolamine binding protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PI3 peptidase inhibitor 3, skin-derived
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
PRDX1 peroxiredoxin 1
PRSS3 protease, serine, 3
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAB11A RAB11A, member RAS oncogene family
RAB14 RAB14, member RAS oncogene family
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RNF4 ring finger protein 4
RPA1 replication protein A1, 70kDa
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEPT11 septin 11
SEPT9 septin 9
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SET SET nuclear proto-oncogene
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35F2 solute carrier family 35, member F2
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SRSF1 serine/arginine-rich splicing factor 1
SSR1 signal sequence receptor, alpha
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TM9SF2 transmembrane 9 superfamily member 2
TM9SF3 transmembrane 9 superfamily member 3
TMEM2 transmembrane protein 2
TMX1 thioredoxin-related transmembrane protein 1
TRAM1 translocation associated membrane protein 1
TRIM14 tripartite motif containing 14
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
UBE3C ubiquitin protein ligase E3C
UNC13B unc-13 homolog B (C. elegans)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
Funding