BRD-K25737009_-666_T3M10_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K25737009_-666_T3M10_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ANKRD12 ankyrin repeat domain 12
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
CADM1 cell adhesion molecule 1
CCDC59 coiled-coil domain containing 59
CCL19 chemokine (C-C motif) ligand 19
CCR7 chemokine (C-C motif) receptor 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CHIC2 cysteine-rich hydrophobic domain 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF5 eukaryotic translation initiation factor 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LGALS2 lectin, galactoside-binding, soluble, 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
NDRG1 N-myc downstream regulated 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
OSER1 oxidative stress responsive serine-rich 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAD9A RAD9 homolog A (S. pombe)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RNF19B ring finger protein 19B
SIK3 SIK family kinase 3
SIRT1 sirtuin 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOX9 SRY (sex determining region Y)-box 9
STX1A syntaxin 1A (brain)
TEX10 testis expressed 10
TGFA transforming growth factor, alpha
TMEM176B transmembrane protein 176B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TSC22D2 TSC22 domain family, member 2
TSPAN4 tetraspanin 4
TSPYL5 TSPY-like 5
UBAP1 ubiquitin associated protein 1
WAC WW domain containing adaptor with coiled-coil
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
ZBTB10 zinc finger and BTB domain containing 10
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ANXA4 annexin A4
APMAP adipocyte plasma membrane associated protein
AREG amphiregulin
CA12 carbonic anhydrase XII
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
COL4A1 collagen, type IV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
EPCAM epithelial cell adhesion molecule
FABP4 fatty acid binding protein 4, adipocyte
FASN fatty acid synthase
FST follistatin
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LPL lipoprotein lipase
MAOA monoamine oxidase A
MMD monocyte to macrophage differentiation-associated
MYOF myoferlin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
OXA1L oxidase (cytochrome c) assembly 1-like
P3H2 prolyl 3-hydroxylase 2
PIR pirin (iron-binding nuclear protein)
PLS3 plastin 3
PON2 paraoxonase 2
PPOX protoporphyrinogen oxidase
PRSS23 protease, serine, 23
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCARD PYD and CARD domain containing
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPD surfactant protein D
SLC46A3 solute carrier family 46, member 3
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TPD52L1 tumor protein D52-like 1
TPGS2 tubulin polyglutamylase complex subunit 2
TPM2 tropomyosin 2 (beta)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
WFDC2 WAP four-disulfide core domain 2
Funding