BRD-K25737009_-666_VCAP_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

284 genes differentially expressed following the BRD-K25737009_-666_VCAP_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASPN asporin
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
C5 complement component 5
CA4 carbonic anhydrase IV
CARS cysteinyl-tRNA synthetase
CCL2 chemokine (C-C motif) ligand 2
CCPG1 cell cycle progression 1
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLIC4 chloride intracellular channel 4
COL15A1 collagen, type XV, alpha 1
CTH cystathionine gamma-lyase
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DMD dystrophin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
DST dystonin
EFS embryonal Fyn-associated substrate
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FGFR1 fibroblast growth factor receptor 1
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GCLC glutamate-cysteine ligase, catalytic subunit
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GRB10 growth factor receptor-bound protein 10
GSN gelsolin
GTPBP2 GTP binding protein 2
GUSBP3 glucuronidase, beta pseudogene 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KLF4 Kruppel-like factor 4 (gut)
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LARP6 La ribonucleoprotein domain family, member 6
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
LRMP lymphoid-restricted membrane protein
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1B microtubule-associated protein 1B
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
NBPF10 neuroblastoma breakpoint family, member 10
NCF2 neutrophil cytosolic factor 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRCAM neuronal cell adhesion molecule
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PERP PERP, TP53 apoptosis effector
PIEZO2 piezo-type mechanosensitive ion channel component 2
PPAP2B phosphatidic acid phosphatase type 2B
PRSS16 protease, serine, 16 (thymus)
PSAT1 phosphoserine aminotransferase 1
QPCT glutaminyl-peptide cyclotransferase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
SARS seryl-tRNA synthetase
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SGK1 serum/glucocorticoid regulated kinase 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SKAP2 src kinase associated phosphoprotein 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
YIPF6 Yip1 domain family, member 6
YPEL5 yippee-like 5 (Drosophila)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADRB2 adrenoceptor beta 2, surface
AHCY adenosylhomocysteinase
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
B3GNT1
BARD1 BRCA1 associated RING domain 1
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBR3 carbonyl reductase 3
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD320 CD320 molecule
CD9 CD9 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
DBF4 DBF4 zinc finger
DCXR dicarbonyl/L-xylulose reductase
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNA2 DNA replication helicase/nuclease 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX1 glutathione peroxidase 1
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HN1L hematological and neurological expressed 1-like
HOMER2 homer scaffolding protein 2
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICMT isoprenylcysteine carboxyl methyltransferase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MPC2 mitochondrial pyruvate carrier 2
MRPL12 mitochondrial ribosomal protein L12
MRPL20 mitochondrial ribosomal protein L20
MRPS30 mitochondrial ribosomal protein S30
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEFH neurofilament, heavy polypeptide
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NOP56 NOP56 ribonucleoprotein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP85 nucleoporin 85kDa
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRC1 protein regulator of cytokinesis 1
QDPR quinoid dihydropteridine reductase
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHCBP1 SHC SH2-domain binding protein 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRSF2 serine/arginine-rich splicing factor 2
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TECR trans-2,3-enoyl-CoA reductase
TEX10 testis expressed 10
THBS1 thrombospondin 1
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
Funding