BRD-K25906698_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K25906698_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ANXA1 annexin A1
BPI bactericidal/permeability-increasing protein
CCL5 chemokine (C-C motif) ligand 5
CD9 CD9 molecule
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CXCL9 chemokine (C-X-C motif) ligand 9
DEFA4 defensin, alpha 4, corticostatin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ELANE elastase, neutrophil expressed
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPX3 glutathione peroxidase 3
GSAP gamma-secretase activating protein
HBE1 hemoglobin, epsilon 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFITM3 interferon induced transmembrane protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KLF9 Kruppel-like factor 9
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS8 lectin, galactoside-binding, soluble, 8
LTF lactotransferrin
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
NAV3 neuron navigator 3
NDRG1 N-myc downstream regulated 1
OBSL1 obscurin-like 1
ODC1 ornithine decarboxylase 1
PDGFC platelet derived growth factor C
PERP PERP, TP53 apoptosis effector
PRAME preferentially expressed antigen in melanoma
PRCP prolylcarboxypeptidase (angiotensinase C)
PRUNE prune exopolyphosphatase
PTPRF protein tyrosine phosphatase, receptor type, F
RGS2 regulator of G-protein signaling 2
RORA RAR-related orphan receptor A
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TUBA4A tubulin, alpha 4a

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C14ORF132 chromosome 14 open reading frame 132
C1ORF56 chromosome 1 open reading frame 56
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
C9ORF3 chromosome 9 open reading frame 3
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND2 cyclin D2
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DLD dihydrolipoamide dehydrogenase
DMBT1 deleted in malignant brain tumors 1
DUSP3 dual specificity phosphatase 3
EDNRB endothelin receptor type B
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
FCGBP Fc fragment of IgG binding protein
FGFBP1 fibroblast growth factor binding protein 1
FRZB frizzled-related protein
GOLGA4 golgin A4
GPM6B glycoprotein M6B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
INHBB inhibin, beta B
LAMB1 laminin, beta 1
LAMP5 lysosomal-associated membrane protein family, member 5
LPL lipoprotein lipase
MAB21L2 mab-21-like 2 (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MATN2 matrilin 2
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MED13L mediator complex subunit 13-like
MOXD1 monooxygenase, DBH-like 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MX2 MX dynamin-like GTPase 2
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NFIB nuclear factor I/B
NRCAM neuronal cell adhesion molecule
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OXA1L oxidase (cytochrome c) assembly 1-like
PHB prohibitin
PLAGL1 pleiomorphic adenoma gene-like 1
PODXL podocalyxin-like
PROM1 prominin 1
PSPH phosphoserine phosphatase
PTBP2 polypyrimidine tract binding protein 2
PXDN peroxidasin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBMS1 RNA binding motif, single stranded interacting protein 1
RCAN1 regulator of calcineurin 1
RET ret proto-oncogene
SCAND1 SCAN domain containing 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SYT1 synaptotagmin I
TDG thymine-DNA glycosylase
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TMED2 transmembrane emp24 domain trafficking protein 2
TPBG trophoblast glycoprotein
TSPAN8 tetraspanin 8
TYRP1 tyrosinase-related protein 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VDAC1 voltage-dependent anion channel 1
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFAND6 zinc finger, AN1-type domain 6
ZNF652 zinc finger protein 652
ZW10 zw10 kinetochore protein
Funding