BRD-K26134695_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K26134695_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
BEX4 brain expressed, X-linked 4
CCR2 chemokine (C-C motif) receptor 2
CNPY3 canopy FGF signaling regulator 3
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL10 chemokine (C-X-C motif) ligand 10
DOK5 docking protein 5
EIF5 eukaryotic translation initiation factor 5
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FGL2 fibrinogen-like 2
FTH1 ferritin, heavy polypeptide 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GOLGA8B golgin A8 family, member B
H2AFV H2A histone family, member V
HIST1H1C histone cluster 1, H1c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFNAR1 interferon (alpha, beta and omega) receptor 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA0355 KIAA0355
LPAR6 lysophosphatidic acid receptor 6
MEST mesoderm specific transcript
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NXN nucleoredoxin
ORC1 origin recognition complex, subunit 1
P3H2 prolyl 3-hydroxylase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PEA15 phosphoprotein enriched in astrocytes 15
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PON3 paraoxonase 3
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRAME preferentially expressed antigen in melanoma
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RPL10 ribosomal protein L10
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SHB Src homology 2 domain containing adaptor protein B
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX17 SRY (sex determining region Y)-box 17
SULF1 sulfatase 1
TES testin LIM domain protein
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
AGR2 anterior gradient 2
AKR1C2 aldo-keto reductase family 1, member C2
ARPC5L actin related protein 2/3 complex, subunit 5-like
BACE2 beta-site APP-cleaving enzyme 2
BMI1 BMI1 proto-oncogene, polycomb ring finger
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CSRP1 cysteine and glycine-rich protein 1
CTSG cathepsin G
CXCL8 chemokine (C-X-C motif) ligand 8
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAR2 fatty acyl CoA reductase 2
FSTL1 follistatin-like 1
GOLIM4 golgi integral membrane protein 4
GSN gelsolin
KANK2 KN motif and ankyrin repeat domains 2
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MFSD10 major facilitator superfamily domain containing 10
MGP matrix Gla protein
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCDH9 protocadherin 9
PGC progastricsin (pepsinogen C)
PLAC8 placenta-specific 8
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCH protein kinase C, eta
PSCA prostate stem cell antigen
PTGES prostaglandin E synthase
QDPR quinoid dihydropteridine reductase
S100P S100 calcium binding protein P
SERBP1 SERPINE1 mRNA binding protein 1
SET SET nuclear proto-oncogene
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORD sorbitol dehydrogenase
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
Funding