BRD-K26756394_VE821_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K26756394_VE821_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CD47 CD47 molecule
CRISP3 cysteine-rich secretory protein 3
CTSD cathepsin D
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FTH1 ferritin, heavy polypeptide 1
GARS glycyl-tRNA synthetase
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ISG15 ISG15 ubiquitin-like modifier
LMO3 LIM domain only 3 (rhombotin-like 2)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRP1 neuropilin 1
PLK2 polo-like kinase 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
SRGN serglycin
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
AFP alpha-fetoprotein
AK4 adenylate kinase 4
ALB albumin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CES1 carboxylesterase 1
CLU clusterin
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRELD2 cysteine-rich with EGF-like domains 2
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAS Fas cell surface death receptor
FGFR3 fibroblast growth factor receptor 3
GPC3 glypican 3
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
HES1 hes family bHLH transcription factor 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IRF8 interferon regulatory factor 8
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LTBP2 latent transforming growth factor beta binding protein 2
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MN1 meningioma (disrupted in balanced translocation) 1
MXRA7 matrix-remodelling associated 7
MYCBP MYC binding protein
NBL1 neuroblastoma 1, DAN family BMP antagonist
PLBD1 phospholipase B domain containing 1
PLXNB2 plexin B2
POSTN periostin, osteoblast specific factor
PTGIS prostaglandin I2 (prostacyclin) synthase
RPL37A ribosomal protein L37a
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SMAD7 SMAD family member 7
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SYNM synemin, intermediate filament protein
TES testin LIM domain protein
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
VCAM1 vascular cell adhesion molecule 1
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
Funding