BRD-K26756394_VE821_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K26756394_VE821_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BHLHE41 basic helix-loop-helix family, member e41
CD38 CD38 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
COPS8 COP9 signalosome subunit 8
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EPAS1 endothelial PAS domain protein 1
FOXG1 forkhead box G1
FXYD2 FXYD domain containing ion transport regulator 2
GCLC glutamate-cysteine ligase, catalytic subunit
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
HDDC2 HD domain containing 2
IFRD2 interferon-related developmental regulator 2
IL7R interleukin 7 receptor
LAPTM4B lysosomal protein transmembrane 4 beta
LCK LCK proto-oncogene, Src family tyrosine kinase
LPAR6 lysophosphatidic acid receptor 6
MAL mal, T-cell differentiation protein
MMP7 matrix metallopeptidase 7
MT1M metallothionein 1M
NQO1 NAD(P)H dehydrogenase, quinone 1
PPAP2A phosphatidic acid phosphatase type 2A
PRKCQ protein kinase C, theta
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SFRP4 secreted frizzled-related protein 4
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
TM4SF1 transmembrane 4 L six family member 1
VAT1 vesicle amine transport 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AHNAK AHNAK nucleoprotein
C3ORF14 chromosome 3 open reading frame 14
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
EXOSC4 exosome component 4
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
GATA6 GATA binding protein 6
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
LMO4 LIM domain only 4
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MFAP2 microfibrillar-associated protein 2
MSH6 mutS homolog 6
PGRMC1 progesterone receptor membrane component 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAD21 RAD21 homolog (S. pombe)
RHOB ras homolog family member B
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STMN1 stathmin 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF3 trefoil factor 3 (intestinal)
TUSC3 tumor suppressor candidate 3
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
Funding