BRD-K26831771_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K26831771_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CTSZ cathepsin Z
EGFL6 EGF-like-domain, multiple 6
FOLR1 folate receptor 1 (adult)
GATA6 GATA binding protein 6
HIST1H2BG histone cluster 1, H2bg
HNMT histamine N-methyltransferase
IGKV4-1 immunoglobulin kappa variable 4-1
KRT19 keratin 19, type I
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
SCGB1D2 secretoglobin, family 1D, member 2
SPINK1 serine peptidase inhibitor, Kazal type 1

decreased expression

Symbol Name
CALML5 calmodulin-like 5
DEGS1 delta(4)-desaturase, sphingolipid 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FADS2 fatty acid desaturase 2
FAM134B family with sequence similarity 134, member B
FGF13 fibroblast growth factor 13
G6PD glucose-6-phosphate dehydrogenase
HDAC9 histone deacetylase 9
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC10 homeobox C10
IGFBP7 insulin-like growth factor binding protein 7
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP1B microtubule-associated protein 1B
MBOAT7 membrane bound O-acyltransferase domain containing 7
NEFL neurofilament, light polypeptide
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NRN1 neuritin 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PEG10 paternally expressed 10
PKM pyruvate kinase, muscle
PNMA2 paraneoplastic Ma antigen 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAD23B RAD23 homolog B (S. cerevisiae)
REEP1 receptor accessory protein 1
RHOB ras homolog family member B
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STK39 serine threonine kinase 39
STOM stomatin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
UGCG UDP-glucose ceramide glucosyltransferase
Funding