BRD-K26997899_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-K26997899_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ANXA1 annexin A1
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BTG3 BTG family, member 3
CAB39 calcium binding protein 39
CALD1 caldesmon 1
CD24 CD24 molecule
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIP1 CAP-GLY domain containing linker protein 1
CREB5 cAMP responsive element binding protein 5
CYR61 cysteine-rich, angiogenic inducer, 61
DIO2 deiodinase, iodothyronine, type II
DSC2 desmocollin 2
DSG3 desmoglein 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EDN3 endothelin 3
EGFR epidermal growth factor receptor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN2 fibrillin 2
FERMT2 fermitin family member 2
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX1 glutathione peroxidase 1
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
IGFBP7 insulin-like growth factor binding protein 7
ILK integrin-linked kinase
INHBA inhibin, beta A
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPZL2 myelin protein zero-like 2
MT1X metallothionein 1X
MT2A metallothionein 2A
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NRG1 neuregulin 1
PALLD palladin, cytoskeletal associated protein
PDLIM5 PDZ and LIM domain 5
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
PPARD peroxisome proliferator-activated receptor delta
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRSS23 protease, serine, 23
PSD3 pleckstrin and Sec7 domain containing 3
RCAN1 regulator of calcineurin 1
RHOD ras homolog family member D
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A14 S100 calcium binding protein A14
S100A2 S100 calcium binding protein A2
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TJP1 tight junction protein 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TRIO trio Rho guanine nucleotide exchange factor
TSC22D2 TSC22 domain family, member 2
TSPAN5 tetraspanin 5
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ASS1 argininosuccinate synthase 1
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
CA12 carbonic anhydrase XII
CDC25B cell division cycle 25B
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL8 chemokine (C-X-C motif) ligand 8
DENND2D DENN/MADD domain containing 2D
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF4B eukaryotic translation initiation factor 4B
EML3 echinoderm microtubule associated protein like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
GATA2 GATA binding protein 2
GPX2 glutathione peroxidase 2
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HOXC6 homeobox C6
HOXD1 homeobox D1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IER3 immediate early response 3
KAZN kazrin, periplakin interacting protein
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRIP1 nuclear receptor interacting protein 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLBD1 phospholipase B domain containing 1
PODXL podocalyxin-like
PPA2 pyrophosphatase (inorganic) 2
PSAT1 phosphoserine aminotransferase 1
PTCH1 patched 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RAP1GAP RAP1 GTPase activating protein
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
Funding