BRD-K27630941_N-(2-methoxyphenyl)-4-morpholino-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act01_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K27630941_N-(2-methoxyphenyl)-4-morpholino-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act01_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRG1 adhesion G protein-coupled receptor G1
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
ANGPTL2 angiopoietin-like 2
APOD apolipoprotein D
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ATF3 activating transcription factor 3
ATP9A ATPase, class II, type 9A
AVPI1 arginine vasopressin-induced 1
BASP1 brain abundant, membrane attached signal protein 1
C14ORF132 chromosome 14 open reading frame 132
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CTSK cathepsin K
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPP4 dipeptidyl-peptidase 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENO2 enolase 2 (gamma, neuronal)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FTH1 ferritin, heavy polypeptide 1
GAS1 growth arrest-specific 1
GEM GTP binding protein overexpressed in skeletal muscle
GNPDA1 glucosamine-6-phosphate deaminase 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IL24 interleukin 24
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MLPH melanophilin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOV nephroblastoma overexpressed
PCP4 Purkinje cell protein 4
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PLIN2 perilipin 2
PRELP proline/arginine-rich end leucine-rich repeat protein
PRUNE2 prune homolog 2 (Drosophila)
PTPRK protein tyrosine phosphatase, receptor type, K
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
SCG5 secretogranin V
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLN sarcolipin
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPON1 spondin 1, extracellular matrix protein
SQSTM1 sequestosome 1
TACC2 transforming, acidic coiled-coil containing protein 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BCHE butyrylcholinesterase
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHEK2 checkpoint kinase 2
CLC Charcot-Leyden crystal galectin
COL3A1 collagen, type III, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSV cathepsin V
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
IL6ST interleukin 6 signal transducer
KRT13 keratin 13, type I
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC17 leucine rich repeat containing 17
MGP matrix Gla protein
PITX1 paired-like homeodomain 1
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS5 regulator of G-protein signaling 5
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR3 small proline-rich protein 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
Funding