BRD-K28120860_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K28120860_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CALCOCO2 calcium binding and coiled-coil domain 2
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNA1 cyclin A1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
COL3A1 collagen, type III, alpha 1
CTH cystathionine gamma-lyase
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DUSP1 dual specificity phosphatase 1
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
H1F0 H1 histone family, member 0
HAPLN1 hyaluronan and proteoglycan link protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IFRD1 interferon-related developmental regulator 1
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
INHBE inhibin, beta E
ITM2A integral membrane protein 2A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
LARP6 La ribonucleoprotein domain family, member 6
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARS methionyl-tRNA synthetase
MOCOS molybdenum cofactor sulfurase
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLCB4 phospholipase C, beta 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RABGAP1L RAB GTPase activating protein 1-like
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TCEA1 transcription elongation factor A (SII), 1
TFF3 trefoil factor 3 (intestinal)
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
AURKA aurora kinase A
B3GNT1
BCHE butyrylcholinesterase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNF cyclin F
CFI complement factor I
CTSH cathepsin H
DPYD dihydropyrimidine dehydrogenase
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
FLRT2 fibronectin leucine rich transmembrane protein 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL27RA interleukin 27 receptor, alpha
KIF20A kinesin family member 20A
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEIS2 Meis homeobox 2
PLK1 polo-like kinase 1
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSRC1 proline/serine-rich coiled-coil 1
RANBP6 RAN binding protein 6
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SHCBP1 SHC SH2-domain binding protein 1
SPON1 spondin 1, extracellular matrix protein
UBE2S ubiquitin-conjugating enzyme E2S