BRD-K28120860_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K28120860_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ADGRG6 adhesion G protein-coupled receptor G6
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOLD1 apolipoprotein L domain containing 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV2 caveolin 2
CD9 CD9 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CHN2 chimerin 2
CSTA cystatin A (stefin A)
CTBP2 C-terminal binding protein 2
CTGF connective tissue growth factor
DDIT3 DNA-damage-inducible transcript 3
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
F2RL1 coagulation factor II (thrombin) receptor-like 1
FERMT1 fermitin family member 1
FGFR4 fibroblast growth factor receptor 4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GREM1 gremlin 1, DAN family BMP antagonist
H1F0 H1 histone family, member 0
HIST1H2BC histone cluster 1, H2bc
ICAM2 intercellular adhesion molecule 2
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MDK midkine (neurite growth-promoting factor 2)
MGAM maltase-glucoamylase
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PLAT plasminogen activator, tissue
PPAP2B phosphatidic acid phosphatase type 2B
QKI QKI, KH domain containing, RNA binding
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SASH1 SAM and SH3 domain containing 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPAG9 sperm associated antigen 9
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFA transforming growth factor, alpha
TMEM255A transmembrane protein 255A
TSC22D2 TSC22 domain family, member 2
VWF von Willebrand factor
ZBTB10 zinc finger and BTB domain containing 10
ZFP36 ZFP36 ring finger protein
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD36B ankyrin repeat domain 36B
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARMT1 acidic residue methyltransferase 1
AURKA aurora kinase A
CFB complement factor B
CP ceruloplasmin (ferroxidase)
DCN decorin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EHD3 EH-domain containing 3
ESR1 estrogen receptor 1
FASTKD5 FAST kinase domains 5
FBXO9 F-box protein 9
FLG filaggrin
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GPER1 G protein-coupled estrogen receptor 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
KIF20A kinesin family member 20A
LINC00342 long intergenic non-protein coding RNA 342
LOC100505650 uncharacterized LOC100505650
LRRN3 leucine rich repeat neuronal 3
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
METRN meteorin, glial cell differentiation regulator
MMP9 matrix metallopeptidase 9
NAP1L1 nucleosome assembly protein 1-like 1
NRN1 neuritin 1
PCOLCE procollagen C-endopeptidase enhancer
PGK1 phosphoglycerate kinase 1
PNISR PNN-interacting serine/arginine-rich protein
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSRC1 proline/serine-rich coiled-coil 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMCO4 single-pass membrane protein with coiled-coil domains 4
SRSF11 serine/arginine-rich splicing factor 11
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TNNT1 troponin T type 1 (skeletal, slow)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
USP34 ubiquitin specific peptidase 34
Funding