BRD-K28296557_Akt inhibitor IV_SW948_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_SW948_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADCY9 adenylate cyclase 9
ADGRF5 adhesion G protein-coupled receptor F5
APOB apolipoprotein B
ASPN asporin
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CDCA4 cell division cycle associated 4
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CHGB chromogranin B
CLIC3 chloride intracellular channel 3
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
DIO1 deiodinase, iodothyronine, type I
DLK1 delta-like 1 homolog (Drosophila)
ECHDC2 enoyl CoA hydratase domain containing 2
EGR1 early growth response 1
EZR ezrin
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GREB1 growth regulation by estrogen in breast cancer 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIST1H1C histone cluster 1, H1c
HIST1H4C histone cluster 1, H4c
HOPX HOP homeobox
HPN hepsin
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
INSM1 insulinoma-associated 1
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
LOC100505650 uncharacterized LOC100505650
LPPR4 lipid phosphate phosphatase-related protein type 4
LYZ lysozyme
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MEG3 maternally expressed 3 (non-protein coding)
MEIS1 Meis homeobox 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OBSL1 obscurin-like 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFD platelet derived growth factor D
PDLIM3 PDZ and LIM domain 3
PDZK1 PDZ domain containing 1
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
RCAN2 regulator of calcineurin 2
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SPARCL1 SPARC-like 1 (hevin)
SPRY4 sprouty homolog 4 (Drosophila)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
TCTA T-cell leukemia translocation altered
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM30B transmembrane protein 30B
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TPM4 tropomyosin 4
TUBB2A tubulin, beta 2A class IIa
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
ZG16 zymogen granule protein 16
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADGRE5 adhesion G protein-coupled receptor E5
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA3 annexin A3
APOD apolipoprotein D
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCL2 chemokine (C-C motif) ligand 2
CD47 CD47 molecule
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLGN calmegin
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DCTD dCMP deaminase
DEGS1 delta(4)-desaturase, sphingolipid 1
EIF5A eukaryotic translation initiation factor 5A
FA2H fatty acid 2-hydroxylase
FBN1 fibrillin 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G0S2 G0/G1 switch 2
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTP1 glutathione S-transferase pi 1
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IRS2 insulin receptor substrate 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LAMB3 laminin, beta 3
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYC v-myc avian myelocytomatosis viral oncogene homolog
NKX3-1 NK3 homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NVL nuclear VCP-like
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PRDX1 peroxiredoxin 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RIN2 Ras and Rab interactor 2
RPIA ribose 5-phosphate isomerase A
SEPW1 selenoprotein W, 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STK24 serine/threonine kinase 24
TAGLN2 transgelin 2
TCF12 transcription factor 12
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPD52L1 tumor protein D52-like 1
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
UBE3C ubiquitin protein ligase E3C
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WTAP Wilms tumor 1 associated protein
Funding