BRD-K28907958_-666_TYKNU_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K28907958_-666_TYKNU_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
AREG amphiregulin
ATF3 activating transcription factor 3
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNL1 cyclin L1
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL6A1 collagen, type VI, alpha 1
COMP cartilage oligomeric matrix protein
CTSV cathepsin V
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA4 EPH receptor A4
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN2 fibrillin 2
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FZD5 frizzled class receptor 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GULP1 GULP, engulfment adaptor PTB domain containing 1
H3F3B H3 histone, family 3B (H3.3B)
HAL histidine ammonia-lyase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST2H2BE histone cluster 2, H2be
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF6 Kruppel-like factor 6
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MT1G metallothionein 1G
NBPF10 neuroblastoma breakpoint family, member 10
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OFD1 oral-facial-digital syndrome 1
ORC1 origin recognition complex, subunit 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PILRB paired immunoglobin-like type 2 receptor beta
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SCRG1 stimulator of chondrogenesis 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBX3 T-box 3
THBS1 thrombospondin 1
THBS4 thrombospondin 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TPD52 tumor protein D52
UGDH UDP-glucose 6-dehydrogenase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZDHHC11 zinc finger, DHHC-type containing 11
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
B3GNT1
CCNA2 cyclin A2
CD47 CD47 molecule
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
ESD esterase D
ETV5 ets variant 5
FAM65B family with sequence similarity 65, member B
FXYD2 FXYD domain containing ion transport regulator 2
FXYD5 FXYD domain containing ion transport regulator 5
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HN1 hematological and neurological expressed 1
HOXB7 homeobox B7
HSPA8 heat shock 70kDa protein 8
IL27RA interleukin 27 receptor, alpha
ITFG1 integrin alpha FG-GAP repeat containing 1
KANK1 KN motif and ankyrin repeat domains 1
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
LMO2 LIM domain only 2 (rhombotin-like 1)
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALL mal, T-cell differentiation protein-like
MRPL19 mitochondrial ribosomal protein L19
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMU neuromedin U
NR2F2 nuclear receptor subfamily 2, group F, member 2
OXTR oxytocin receptor
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PDZK1IP1 PDZK1 interacting protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAC8 placenta-specific 8
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PROM1 prominin 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELN reelin
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SET SET nuclear proto-oncogene
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SNX10 sorting nexin 10
SPTBN1 spectrin, beta, non-erythrocytic 1
TAL1 T-cell acute lymphocytic leukemia 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TNS1 tensin 1
TRIM14 tripartite motif containing 14
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
Funding