BRD-K28916077_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K28916077_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
C8ORF4 chromosome 8 open reading frame 4
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CES1 carboxylesterase 1
COL14A1 collagen, type XIV, alpha 1
COL9A3 collagen, type IX, alpha 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
ICAM3 intercellular adhesion molecule 3
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LIPG lipase, endothelial
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP3 matrix metallopeptidase 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
PCDH9 protocadherin 9
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
POSTN periostin, osteoblast specific factor
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SRPX2 sushi-repeat containing protein, X-linked 2
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPBG trophoblast glycoprotein
TRBC1 T cell receptor beta constant 1
TRPS1 trichorhinophalangeal syndrome I
TUFT1 tuftelin 1
WIF1 WNT inhibitory factor 1
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
BACE2 beta-site APP-cleaving enzyme 2
CCND2 cyclin D2
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDK4 cyclin-dependent kinase 4
COCH cochlin
DAPK1 death-associated protein kinase 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
FAM129A family with sequence similarity 129, member A
HSPA1A heat shock 70kDa protein 1A
MAP1B microtubule-associated protein 1B
MCM2 minichromosome maintenance complex component 2
NUP62 nucleoporin 62kDa
PLEKHA5 pleckstrin homology domain containing, family A member 5
PON2 paraoxonase 2
PSPH phosphoserine phosphatase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TFPI2 tissue factor pathway inhibitor 2
TM9SF2 transmembrane 9 superfamily member 2
TRIB3 tribbles pseudokinase 3
WSB2 WD repeat and SOCS box containing 2
ZNF512B zinc finger protein 512B