BRD-K29395450_PIK-93_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K29395450_PIK-93_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP1 aquaporin 1 (Colton blood group)
C10ORF10 chromosome 10 open reading frame 10
CAPG capping protein (actin filament), gelsolin-like
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSTA cystatin A (stefin A)
DCN decorin
DUSP4 dual specificity phosphatase 4
ERMP1 endoplasmic reticulum metallopeptidase 1
FAXDC2 fatty acid hydroxylase domain containing 2
FMOD fibromodulin
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPATCH8 G patch domain containing 8
GRB7 growth factor receptor-bound protein 7
GSTP1 glutathione S-transferase pi 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1R1 interleukin 1 receptor, type I
KRT81 keratin 81, type II
KYNU kynureninase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MLPH melanophilin
MT1M metallothionein 1M
NEBL nebulette
PEX11A peroxisomal biogenesis factor 11 alpha
PIP prolactin-induced protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB13 RAB13, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
S100A14 S100 calcium binding protein A14
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLPI secretory leukocyte peptidase inhibitor
SORBS2 sorbin and SH3 domain containing 2
SRPX sushi-repeat containing protein, X-linked
TGM2 transglutaminase 2
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CNN3 calponin 3, acidic
COL4A5 collagen, type IV, alpha 5
CPB1 carboxypeptidase B1 (tissue)
CSRP2 cysteine and glycine-rich protein 2
FAM129A family with sequence similarity 129, member A
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
IGLL1 immunoglobulin lambda-like polypeptide 1
KRT17 keratin 17, type I
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PTTG1 pituitary tumor-transforming 1
RGS4 regulator of G-protein signaling 4
SPP1 secreted phosphoprotein 1
SUB1 SUB1 homolog (S. cerevisiae)
TES testin LIM domain protein
Funding