BRD-K29950728_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-K29950728_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
BSG basigin (Ok blood group)
CLGN calmegin
CPB1 carboxypeptidase B1 (tissue)
CRISP3 cysteine-rich secretory protein 3
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPNMB glycoprotein (transmembrane) nmb
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LRRC15 leucine rich repeat containing 15
LYPD1 LY6/PLAUR domain containing 1
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAGD Ras-related GTP binding D
RSAD2 radical S-adenosyl methionine domain containing 2
RUNX3 runt-related transcription factor 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TXN thioredoxin
ZNF264 zinc finger protein 264
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
CLTC clathrin, heavy chain (Hc)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP7 fatty acid binding protein 7, brain
HHEX hematopoietically expressed homeobox
LIMCH1 LIM and calponin homology domains 1
MMP12 matrix metallopeptidase 12
MSMB microseminoprotein, beta-
PALLD palladin, cytoskeletal associated protein
PHLDA2 pleckstrin homology-like domain, family A, member 2
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNNT1 troponin T type 1 (skeletal, slow)
Funding