BRD-K30647638_5-amino-1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazole-4-carbonitrile CALI-091-1_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K30647638_5-amino-1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazole-4-carbonitrile CALI-091-1_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
AXL AXL receptor tyrosine kinase
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CLU clusterin
COASY CoA synthase
CST3 cystatin C
CTSB cathepsin B
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
FCMR Fc fragment of IgM receptor
FOSL1 FOS-like antigen 1
GDI2 GDP dissociation inhibitor 2
GRB10 growth factor receptor-bound protein 10
GRWD1 glutamate-rich WD repeat containing 1
IL7R interleukin 7 receptor
M6PR mannose-6-phosphate receptor (cation dependent)
MAP1B microtubule-associated protein 1B
PCDH9 protocadherin 9
PER2 period circadian clock 2
PHGDH phosphoglycerate dehydrogenase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
REG1A regenerating islet-derived 1 alpha
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SRSF6 serine/arginine-rich splicing factor 6
TM9SF3 transmembrane 9 superfamily member 3

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADCY7 adenylate cyclase 7
ASCL1 achaete-scute family bHLH transcription factor 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKM creatine kinase, muscle
COL3A1 collagen, type III, alpha 1
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CST6 cystatin E/M
CXCL14 chemokine (C-X-C motif) ligand 14
DAPK1 death-associated protein kinase 1
DLK1 delta-like 1 homolog (Drosophila)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
EGFL6 EGF-like-domain, multiple 6
FHOD3 formin homology 2 domain containing 3
FOS FBJ murine osteosarcoma viral oncogene homolog
GAS1 growth arrest-specific 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
IGL immunoglobulin lambda locus
LAMP5 lysosomal-associated membrane protein family, member 5
LPL lipoprotein lipase
LXN latexin
MEIS2 Meis homeobox 2
MFAP2 microfibrillar-associated protein 2
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MN1 meningioma (disrupted in balanced translocation) 1
MSMB microseminoprotein, beta-
MX1 MX dynamin-like GTPase 1
MYO1B myosin IB
NEB nebulin
OGFRL1 opioid growth factor receptor-like 1
PAPD7 PAP associated domain containing 7
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PNMA2 paraneoplastic Ma antigen 2
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RBP1 retinol binding protein 1, cellular
RET ret proto-oncogene
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RTN2 reticulon 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SIK1 salt-inducible kinase 1
SNX7 sorting nexin 7
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SWAP70 SWAP switching B-cell complex 70kDa subunit
THBS1 thrombospondin 1
TPD52L1 tumor protein D52-like 1
TTN titin
UBE3B ubiquitin protein ligase E3B
Funding