BRD-K30677119_PP-30_SKLU1_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K30677119_PP-30_SKLU1_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
AMPD3 adenosine monophosphate deaminase 3
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
DHRS7 dehydrogenase/reductase (SDR family) member 7
DST dystonin
EFNA1 ephrin-A1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FGF13 fibroblast growth factor 13
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FXYD6 FXYD domain containing ion transport regulator 6
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HDAC9 histone deacetylase 9
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL32 interleukin 32
INSM1 insulinoma-associated 1
IRF6 interferon regulatory factor 6
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100272216 uncharacterized LOC100272216
MAN1A1 mannosidase, alpha, class 1A, member 1
MFAP5 microfibrillar associated protein 5
NDRG2 NDRG family member 2
NFASC neurofascin
NPY1R neuropeptide Y receptor Y1
OXR1 oxidation resistance 1
PCP4 Purkinje cell protein 4
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTK2 protein tyrosine kinase 2
PTPRK protein tyrosine phosphatase, receptor type, K
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SCARB2 scavenger receptor class B, member 2
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SORBS2 sorbin and SH3 domain containing 2
SOX11 SRY (sex determining region Y)-box 11
ST18 suppression of tumorigenicity 18, zinc finger
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TBC1D31 TBC1 domain family, member 31
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AURKA aurora kinase A
BST2 bone marrow stromal cell antigen 2
CCDC86 coiled-coil domain containing 86
CCDC92 coiled-coil domain containing 92
CD47 CD47 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHMP4A charged multivesicular body protein 4A
COL5A1 collagen, type V, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EIF4A3 eukaryotic translation initiation factor 4A3
EIF5 eukaryotic translation initiation factor 5
FAM46A family with sequence similarity 46, member A
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GSPT1 G1 to S phase transition 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
IL1R2 interleukin 1 receptor, type II
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LMO4 LIM domain only 4
LTBP1 latent transforming growth factor beta binding protein 1
MCUR1 mitochondrial calcium uniporter regulator 1
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOP16 NOP16 nucleolar protein
NOSIP nitric oxide synthase interacting protein
ODC1 ornithine decarboxylase 1
PDLIM1 PDZ and LIM domain 1
PLS1 plastin 1
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
RAD51C RAD51 paralog C
RPL39L ribosomal protein L39-like
S100A10 S100 calcium binding protein A10
SFN stratifin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRSF7 serine/arginine-rich splicing factor 7
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TMEM251 transmembrane protein 251
TRA2B transformer 2 beta homolog (Drosophila)
UBE3C ubiquitin protein ligase E3C
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
YME1L1 YME1-like 1 ATPase
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
Funding