BRD-K30849099_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K30849099_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM69A family with sequence similarity 69, member A
FHL2 four and a half LIM domains 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GADD45B growth arrest and DNA-damage-inducible, beta
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
MAST2 microtubule associated serine/threonine kinase 2
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
PDE4B phosphodiesterase 4B, cAMP-specific
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SCUBE2 signal peptide, CUB domain, EGF-like 2
STC2 stanniocalcin 2
TMEM45A transmembrane protein 45A
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
VNN1 vanin 1

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
BAMBI BMP and activin membrane-bound inhibitor
BTBD3 BTB (POZ) domain containing 3
CASP2 caspase 2, apoptosis-related cysteine peptidase
CTSC cathepsin C
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDNRB endothelin receptor type B
ERBB3 erb-b2 receptor tyrosine kinase 3
FLRT3 fibronectin leucine rich transmembrane protein 3
FZD7 frizzled class receptor 7
GPX2 glutathione peroxidase 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INTS3 integrator complex subunit 3
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MECOM MDS1 and EVI1 complex locus
MGP matrix Gla protein
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NID1 nidogen 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
PHACTR2 phosphatase and actin regulator 2
PLS3 plastin 3
PPARG peroxisome proliferator-activated receptor gamma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRSS23 protease, serine, 23
PVALB parvalbumin
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SKAP2 src kinase associated phosphoprotein 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TMEM2 transmembrane protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
VCAN versican
VSNL1 visinin-like 1
XIST X inactive specific transcript (non-protein coding)
Funding