BRD-K30849099_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K30849099_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CCNF cyclin F
CD24 CD24 molecule
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
COL6A2 collagen, type VI, alpha 2
CTBP2 C-terminal binding protein 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
FOSL2 FOS-like antigen 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GNLY granulysin
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H2BG histone cluster 1, H2bg
IFI16 interferon, gamma-inducible protein 16
IGFBP7 insulin-like growth factor binding protein 7
IPO13 importin 13
KLRK1 killer cell lectin-like receptor subfamily K, member 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
OPTN optineurin
PRNP prion protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIPK2 receptor-interacting serine-threonine kinase 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHOX2 short stature homeobox 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAR steroidogenic acute regulatory protein
THBS2 thrombospondin 2
TIMP2 TIMP metallopeptidase inhibitor 2
TUBA4A tubulin, alpha 4a
VNN1 vanin 1

decreased expression

Symbol Name
APOD apolipoprotein D
CD320 CD320 molecule
CD59 CD59 molecule, complement regulatory protein
CDK6 cyclin-dependent kinase 6
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHMP4A charged multivesicular body protein 4A
CLU clusterin
COBL cordon-bleu WH2 repeat protein
CTTN cortactin
DSP desmoplakin
ENO1 enolase 1, (alpha)
FAM46A family with sequence similarity 46, member A
GLDC glycine dehydrogenase (decarboxylating)
GSTA4 glutathione S-transferase alpha 4
HCLS1 hematopoietic cell-specific Lyn substrate 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMOX1 heme oxygenase 1
IGFBP6 insulin-like growth factor binding protein 6
ISOC1 isochorismatase domain containing 1
MAOB monoamine oxidase B
MTUS1 microtubule associated tumor suppressor 1
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
PDGFD platelet derived growth factor D
PDLIM2 PDZ and LIM domain 2 (mystique)
PENK proenkephalin
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
SEPHS2 selenophosphate synthetase 2
TNIP1 TNFAIP3 interacting protein 1
TPD52L1 tumor protein D52-like 1
ZNF586 zinc finger protein 586
Funding