BRD-K31238592_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

48 genes differentially expressed following the BRD-K31238592_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
BAG3 BCL2-associated athanogene 3
C1ORF115 chromosome 1 open reading frame 115
CACYBP calcyclin binding protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L2 chitinase 3-like 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
FAS Fas cell surface death receptor
GCLM glutamate-cysteine ligase, modifier subunit
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NELL2 NEL-like 2 (chicken)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CYR61 cysteine-rich, angiogenic inducer, 61
DUOX2 dual oxidase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
KRT23 keratin 23, type I
LUM lumican
NKG7 natural killer cell granule protein 7
PLN phospholamban
PRSS23 protease, serine, 23
RGS13 regulator of G-protein signaling 13
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC38A10 solute carrier family 38, member 10
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TYRP1 tyrosinase-related protein 1