BRD-K31238592_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K31238592_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AK1 adenylate kinase 1
AQP3 aquaporin 3 (Gill blood group)
BLMH bleomycin hydrolase
CCND2 cyclin D2
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CRYAB crystallin, alpha B
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSE dermatan sulfate epimerase
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GPX3 glutathione peroxidase 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IFRD1 interferon-related developmental regulator 1
ISCU iron-sulfur cluster assembly enzyme
ITM2A integral membrane protein 2A
KDM5D lysine (K)-specific demethylase 5D
LITAF lipopolysaccharide-induced TNF factor
LY6D lymphocyte antigen 6 complex, locus D
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
NOTCH1 notch 1
PIR pirin (iron-binding nuclear protein)
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PTGES prostaglandin E synthase
REXO2 RNA exonuclease 2
RHCG Rh family, C glycoprotein
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
STOM stomatin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TUBA4A tubulin, alpha 4a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ALDOB aldolase B, fructose-bisphosphate
AUTS2 autism susceptibility candidate 2
BCL6 B-cell CLL/lymphoma 6
CD200 CD200 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CLDN3 claudin 3
DCN decorin
DPYSL3 dihydropyrimidinase-like 3
FAIM Fas apoptotic inhibitory molecule
FAP fibroblast activation protein, alpha
FBP1 fructose-1,6-bisphosphatase 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H2BG histone cluster 1, H2bg
IGFBP7 insulin-like growth factor binding protein 7
IPO13 importin 13
KRT19 keratin 19, type I
LUM lumican
MEIS1 Meis homeobox 1
MMP12 matrix metallopeptidase 12
MSLN mesothelin
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
PBX1 pre-B-cell leukemia homeobox 1
PDGFC platelet derived growth factor C
PIP prolactin-induced protein
PRSS2 protease, serine, 2 (trypsin 2)
RGS4 regulator of G-protein signaling 4
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMC5 transmembrane channel-like 5
TMEM30B transmembrane protein 30B
TRIB2 tribbles pseudokinase 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
XIST X inactive specific transcript (non-protein coding)