BRD-K31542390_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-K31542390_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
BLVRB biliverdin reductase B
CCNE2 cyclin E2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DHRS2 dehydrogenase/reductase (SDR family) member 2
FDXR ferredoxin reductase
GDF15 growth differentiation factor 15
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRF9 interferon regulatory factor 9
MAN1A1 mannosidase, alpha, class 1A, member 1
PDLIM3 PDZ and LIM domain 3
RAMP1 receptor (G protein-coupled) activity modifying protein 1
REG1A regenerating islet-derived 1 alpha
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
TMOD1 tropomodulin 1
TPD52L1 tumor protein D52-like 1

decreased expression

Symbol Name
ATF1 activating transcription factor 1
AURKA aurora kinase A
BAD BCL2-associated agonist of cell death
C8ORF4 chromosome 8 open reading frame 4
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
KIF14 kinesin family member 14
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIB nuclear factor I/B
PLK1 polo-like kinase 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PSRC1 proline/serine-rich coiled-coil 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPP1 selenoprotein P, plasma, 1
SGCE sarcoglycan, epsilon
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOSTDC1 sclerostin domain containing 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
TNS3 tensin 3