BRD-K31706415_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K31706415_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD11 ankyrin repeat domain 11
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
CARS cysteinyl-tRNA synthetase
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
H1F0 H1 histone family, member 0
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
LPIN1 lipin 1
MARS methionyl-tRNA synthetase
MID1IP1 MID1 interacting protein 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PDIA4 protein disulfide isomerase family A, member 4
PSAT1 phosphoserine aminotransferase 1
PXDN peroxidasin
RSAD2 radical S-adenosyl methionine domain containing 2
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24D SEC24 family member D
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SRP72 signal recognition particle 72kDa
TGFA transforming growth factor, alpha
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UFM1 ubiquitin-fold modifier 1
USP18 ubiquitin specific peptidase 18
VEGFA vascular endothelial growth factor A
VIM vimentin
XPOT exportin, tRNA

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
C8ORF4 chromosome 8 open reading frame 4
CCL4 chemokine (C-C motif) ligand 4
CD14 CD14 molecule
CES1 carboxylesterase 1
COL4A5 collagen, type IV, alpha 5
CTSV cathepsin V
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DLK1 delta-like 1 homolog (Drosophila)
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ERMP1 endoplasmic reticulum metallopeptidase 1
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KRT17 keratin 17, type I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEIS1 Meis homeobox 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NRCAM neuronal cell adhesion molecule
OXTR oxytocin receptor
PDGFA platelet-derived growth factor alpha polypeptide
PRKCD protein kinase C, delta
S100A2 S100 calcium binding protein A2
SATB1 SATB homeobox 1
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
STMN1 stathmin 1
TCF4 transcription factor 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMEM14A transmembrane protein 14A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF185 zinc finger protein 185 (LIM domain)