BRD-K31856043_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-K31856043_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA1 carbonic anhydrase I
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CRABP2 cellular retinoic acid binding protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSTN destrin (actin depolymerizing factor)
FABP4 fatty acid binding protein 4, adipocyte
GRIA2 glutamate receptor, ionotropic, AMPA 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
INHBA inhibin, beta A
KRT14 keratin 14, type I
KRT18 keratin 18, type I
LGALS1 lectin, galactoside-binding, soluble, 1
MAP7 microtubule-associated protein 7
MLPH melanophilin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NNMT nicotinamide N-methyltransferase
PIP prolactin-induced protein
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QPCT glutaminyl-peptide cyclotransferase
RGS2 regulator of G-protein signaling 2
S100A4 S100 calcium binding protein A4
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A6 solute carrier family 16, member 6
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A1 solute carrier family 38, member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TPD52 tumor protein D52
TUBB2A tubulin, beta 2A class IIa
VCAN versican
WFDC1 WAP four-disulfide core domain 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AIM2 absent in melanoma 2
CAV2 caveolin 2
CTSH cathepsin H
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
EPB41L2 erythrocyte membrane protein band 4.1-like 2
GPX2 glutathione peroxidase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFI16 interferon, gamma-inducible protein 16
LDLR low density lipoprotein receptor
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MPZL2 myelin protein zero-like 2
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR2F2 nuclear receptor subfamily 2, group F, member 2
PLN phospholamban
RAB2A RAB2A, member RAS oncogene family
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCML1 sex comb on midleg-like 1 (Drosophila)
ZFP36L1 ZFP36 ring finger protein-like 1