BRD-K31856043_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K31856043_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CD24 CD24 molecule
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP4A charged multivesicular body protein 4A
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
EDNRB endothelin receptor type B
ELOVL4 ELOVL fatty acid elongase 4
FADS1 fatty acid desaturase 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GJA1 gap junction protein, alpha 1, 43kDa
HEPH hephaestin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
LOC100505650 uncharacterized LOC100505650
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MEIS2 Meis homeobox 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSLN mesothelin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPTX2 neuronal pentraxin II
NTS neurotensin
PIR pirin (iron-binding nuclear protein)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PRAME preferentially expressed antigen in melanoma
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN2 reticulon 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
C2CD2 C2 calcium-dependent domain containing 2
CAB39 calcium binding protein 39
CYB561 cytochrome b561
EMP1 epithelial membrane protein 1
EREG epiregulin
GPRC5A G protein-coupled receptor, class C, group 5, member A
IGFBP7 insulin-like growth factor binding protein 7
LAMP5 lysosomal-associated membrane protein family, member 5
LDLR low density lipoprotein receptor
LPL lipoprotein lipase
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MGLL monoglyceride lipase
PHB prohibitin
PLAC8 placenta-specific 8
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PRR7 proline rich 7 (synaptic)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Funding