BRD-K31912990_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K31912990_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C6ORF48 chromosome 6 open reading frame 48
CCL20 chemokine (C-C motif) ligand 20
CFD complement factor D (adipsin)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EAF2 ELL associated factor 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FADS1 fatty acid desaturase 1
FKBP14 FK506 binding protein 14, 22 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GCH1 GTP cyclohydrolase 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
KCTD5 potassium channel tetramerization domain containing 5
LDLR low density lipoprotein receptor
LPIN1 lipin 1
MAGEB2 melanoma antigen family B2
MSMO1 methylsterol monooxygenase 1
NANS N-acetylneuraminic acid synthase
NFIL3 nuclear factor, interleukin 3 regulated
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PSAT1 phosphoserine aminotransferase 1
RAD9A RAD9 homolog A (S. pombe)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX9 SRY (sex determining region Y)-box 9
TARS threonyl-tRNA synthetase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPYL2 TSPY-like 2
TUFT1 tuftelin 1
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
VIM vimentin
WIPI1 WD repeat domain, phosphoinositide interacting 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATF5 activating transcription factor 5
BAD BCL2-associated agonist of cell death
BGN biglycan
BMP2 bone morphogenetic protein 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAT catalase
CCND1 cyclin D1
CD93 CD93 molecule
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CXCL9 chemokine (C-X-C motif) ligand 9
FABP4 fatty acid binding protein 4, adipocyte
FASTKD5 FAST kinase domains 5
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
KRT14 keratin 14, type I
KRT5 keratin 5, type II
MECOM MDS1 and EVI1 complex locus
NPY1R neuropeptide Y receptor Y1
PDZK1 PDZ domain containing 1
PFN2 profilin 2
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
PRR7 proline rich 7 (synaptic)
RGS5 regulator of G-protein signaling 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
VWF von Willebrand factor
Funding