BRD-K32010074_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K32010074_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5 arachidonate 5-lipoxygenase
APOC1 apolipoprotein C-I
ATF3 activating transcription factor 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CD163 CD163 molecule
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EMP2 epithelial membrane protein 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GPRC5A G protein-coupled receptor, class C, group 5, member A
HCK HCK proto-oncogene, Src family tyrosine kinase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFI30 interferon, gamma-inducible protein 30
IFRD1 interferon-related developmental regulator 1
IL11 interleukin 11
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
INSIG1 insulin induced gene 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
LAMB3 laminin, beta 3
LST1 leukocyte specific transcript 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCF2 neutrophil cytosolic factor 2
NPC1 Niemann-Pick disease, type C1
PALLD palladin, cytoskeletal associated protein
PDLIM5 PDZ and LIM domain 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SFN stratifin
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
TCL1A T-cell leukemia/lymphoma 1A
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
TYMP thymidine phosphorylase

decreased expression

Symbol Name
ADGRL4 adhesion G protein-coupled receptor L4
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGAP12 Rho GTPase activating protein 12
CCNF cyclin F
CD200 CD200 molecule
CHGB chromogranin B
COL5A2 collagen, type V, alpha 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
ERLIN2 ER lipid raft associated 2
IGF1 insulin-like growth factor 1 (somatomedin C)
NDN necdin, melanoma antigen (MAGE) family member
NID1 nidogen 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCAN2 regulator of calcineurin 2
RGS5 regulator of G-protein signaling 5
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
Funding