BRD-K32896438_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K32896438_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACE2 angiotensin I converting enzyme 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMDHD2 amidohydrolase domain containing 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CACYBP calcyclin binding protein
CAPN6 calpain 6
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLU clusterin
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM46A family with sequence similarity 46, member A
FBP1 fructose-1,6-bisphosphatase 1
FHL2 four and a half LIM domains 2
FMO1 flavin containing monooxygenase 1
FOLR1 folate receptor 1 (adult)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GATAD1 GATA zinc finger domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
INHBE inhibin, beta E
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MARS methionyl-tRNA synthetase
MAST4 microtubule associated serine/threonine kinase family member 4
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RND1 Rho family GTPase 1
SELE selectin E
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53 tumor protein p53
TRIB3 tribbles pseudokinase 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AK4 adenylate kinase 4
ASPH aspartate beta-hydroxylase
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B3GNT1
C11ORF95 chromosome 11 open reading frame 95
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC25B cell division cycle 25B
CLEC2B C-type lectin domain family 2, member B
CRIP2 cysteine-rich protein 2
CYTL1 cytokine-like 1
ELOVL6 ELOVL fatty acid elongase 6
FBLN1 fibulin 1
FBXO21 F-box protein 21
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
KANK2 KN motif and ankyrin repeat domains 2
LBR lamin B receptor
LOXL2 lysyl oxidase-like 2
MGST2 microsomal glutathione S-transferase 2
MN1 meningioma (disrupted in balanced translocation) 1
MREG melanoregulin
PCNA proliferating cell nuclear antigen
PDLIM3 PDZ and LIM domain 3
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
RBP1 retinol binding protein 1, cellular
RBPMS RNA binding protein with multiple splicing
RHOBTB3 Rho-related BTB domain containing 3
RNF130 ring finger protein 130
RRAGD Ras-related GTP binding D
SDC2 syndecan 2
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SH3BP4 SH3-domain binding protein 4
SKAP2 src kinase associated phosphoprotein 2
SNN stannin
ST18 suppression of tumorigenicity 18, zinc finger
TBC1D4 TBC1 domain family, member 4
TM9SF2 transmembrane 9 superfamily member 2
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1