BRD-K33272502_DG-041_A673_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K33272502_DG-041_A673_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ADAMDEC1 ADAM-like, decysin 1
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK2 ankyrin 2, neuronal
ANXA2 annexin A2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUH AU RNA binding protein/enoyl-CoA hydratase
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
CALML4 calmodulin-like 4
CAPN2 calpain 2, (m/II) large subunit
CARS cysteinyl-tRNA synthetase
CCNG2 cyclin G2
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
COCH cochlin
COG5 component of oligomeric golgi complex 5
COL3A1 collagen, type III, alpha 1
CTH cystathionine gamma-lyase
CXCL9 chemokine (C-X-C motif) ligand 9
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKBP11 FK506 binding protein 11, 19 kDa
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
H1F0 H1 histone family, member 0
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H4C histone cluster 1, H4c
HSPA13 heat shock protein 70kDa family, member 13
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IRS2 insulin receptor substrate 2
KLF9 Kruppel-like factor 9
KRT15 keratin 15, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LUM lumican
MARS methionyl-tRNA synthetase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP12 matrix metallopeptidase 12
MTFR1 mitochondrial fission regulator 1
MTSS1 metastasis suppressor 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PDE4DIP phosphodiesterase 4D interacting protein
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNASE4 ribonuclease, RNase A family, 4
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
STC2 stanniocalcin 2
SULF1 sulfatase 1
TARS threonyl-tRNA synthetase
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TMEM135 transmembrane protein 135
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TSPYL5 TSPY-like 5
TTN titin
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ASRGL1 asparaginase like 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
C8ORF4 chromosome 8 open reading frame 4
CCNE2 cyclin E2
CD47 CD47 molecule
CD93 CD93 molecule
CDC42 cell division cycle 42
CLC Charcot-Leyden crystal galectin
CLDN5 claudin 5
COPS7A COP9 signalosome subunit 7A
CSRP1 cysteine and glycine-rich protein 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM107A family with sequence similarity 107, member A
FLNA filamin A, alpha
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
GPM6A glycoprotein M6A
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
KIAA0100 KIAA0100
KLHDC8A kelch domain containing 8A
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK8 kallikrein-related peptidase 8
LAPTM4B lysosomal protein transmembrane 4 beta
LOC100505650 uncharacterized LOC100505650
LOC283683 uncharacterized LOC283683
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPL lipoprotein lipase
LYPD1 LY6/PLAUR domain containing 1
MGLL monoglyceride lipase
MMP11 matrix metallopeptidase 11
MMP7 matrix metallopeptidase 7
MX2 MX dynamin-like GTPase 2
NCALD neurocalcin delta
NCAN neurocan
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PWP1 PWP1 homolog (S. cerevisiae)
RNF167 ring finger protein 167
SCGB2A1 secretoglobin, family 2A, member 1
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
SST somatostatin
STX1A syntaxin 1A (brain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
TM4SF1 transmembrane 4 L six family member 1
TUBA4A tubulin, alpha 4a
UBE2S ubiquitin-conjugating enzyme E2S
VGLL4 vestigial-like family member 4
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZYX zyxin
Funding