BRD-K33272502_DG-041_DV90_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K33272502_DG-041_DV90_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRG2 adhesion G protein-coupled receptor G2
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AREG amphiregulin
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BMP2 bone morphogenetic protein 2
C1ORF116 chromosome 1 open reading frame 116
C2CD2 C2 calcium-dependent domain containing 2
C9ORF3 chromosome 9 open reading frame 3
CD9 CD9 molecule
CDC42 cell division cycle 42
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
EGR1 early growth response 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EREG epiregulin
ESRP1 epithelial splicing regulatory protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAIM Fas apoptotic inhibitory molecule
FDX1 ferredoxin 1
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FST follistatin
G0S2 G0/G1 switch 2
GNAS GNAS complex locus
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
JUN jun proto-oncogene
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGP matrix Gla protein
MIR22HG MIR22 host gene
MX1 MX dynamin-like GTPase 1
MYBPC1 myosin binding protein C, slow type
NEBL nebulette
NET1 neuroepithelial cell transforming 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
PERP PERP, TP53 apoptosis effector
PHACTR2 phosphatase and actin regulator 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSPH phosphoserine phosphatase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC38A1 solute carrier family 38, member 1
SMAD3 SMAD family member 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
WSB1 WD repeat and SOCS box containing 1
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AES amino-terminal enhancer of split
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
CFB complement factor B
CST7 cystatin F (leukocystatin)
CXCL5 chemokine (C-X-C motif) ligand 5
EFCAB14 EF-hand calcium binding domain 14
EMP3 epithelial membrane protein 3
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FZD7 frizzled class receptor 7
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HSPA2 heat shock 70kDa protein 2
IGHM immunoglobulin heavy constant mu
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LTF lactotransferrin
MMP12 matrix metallopeptidase 12
MNDA myeloid cell nuclear differentiation antigen
MRPS30 mitochondrial ribosomal protein S30
MTSS1 metastasis suppressor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
NT5DC2 5'-nucleotidase domain containing 2
PDGFC platelet derived growth factor C
PDZK1IP1 PDZK1 interacting protein 1
PLAT plasminogen activator, tissue
RNF167 ring finger protein 167
RUNX3 runt-related transcription factor 3
S100A7 S100 calcium binding protein A7
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC46A3 solute carrier family 46, member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STK10 serine/threonine kinase 10
STOM stomatin
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNL4B thioredoxin-like 4B
WT1 Wilms tumor 1
ZNF266 zinc finger protein 266
Funding