BRD-K33272502_DG-041_EFO27_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K33272502_DG-041_EFO27_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ABI1 abl-interactor 1
ADK adenosine kinase
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATG3 autophagy related 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BASP1 brain abundant, membrane attached signal protein 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C6ORF48 chromosome 6 open reading frame 48
CAPN2 calpain 2, (m/II) large subunit
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHPT1 choline phosphotransferase 1
CLDN10 claudin 10
CLIC4 chloride intracellular channel 4
CRIP1 cysteine-rich protein 1 (intestinal)
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FKBP11 FK506 binding protein 11, 19 kDa
GARS glycyl-tRNA synthetase
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
LINC00341 long intergenic non-protein coding RNA 341
LYPLA1 lysophospholipase I
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MRPS30 mitochondrial ribosomal protein S30
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO6 myosin VI
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
OXSR1 oxidative stress responsive 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RB1CC1 RB1-inducible coiled-coil 1
RIPK2 receptor-interacting serine-threonine kinase 2
RSL24D1 ribosomal L24 domain containing 1
S100A10 S100 calcium binding protein A10
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TCEA1 transcription elongation factor A (SII), 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
USP1 ubiquitin specific peptidase 1
WAC WW domain containing adaptor with coiled-coil
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADAT1 adenosine deaminase, tRNA-specific 1
ADM adrenomedullin
ANKRD36B ankyrin repeat domain 36B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC2 baculoviral IAP repeat containing 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCL8 chemokine (C-C motif) ligand 8
CD40 CD40 molecule, TNF receptor superfamily member 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNPY3 canopy FGF signaling regulator 3
CTSZ cathepsin Z
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
FGL2 fibrinogen-like 2
FYB FYN binding protein
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC6 homeobox C6
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IFI44L interferon-induced protein 44-like
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ILF3 interleukin enhancer binding factor 3, 90kDa
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KRT23 keratin 23, type I
LAMA4 laminin, alpha 4
LBH limb bud and heart development
MAT2A methionine adenosyltransferase II, alpha
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MX1 MX dynamin-like GTPase 1
NEFH neurofilament, heavy polypeptide
NT5DC2 5'-nucleotidase domain containing 2
P3H2 prolyl 3-hydroxylase 2
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PDE4B phosphodiesterase 4B, cAMP-specific
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLBD1 phospholipase B domain containing 1
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SON SON DNA binding protein
SPP1 secreted phosphoprotein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM164 transmembrane protein 164
TMEM204 transmembrane protein 204
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
Funding