BRD-K33272502_DG-041_HA1E_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

258 genes differentially expressed following the BRD-K33272502_DG-041_HA1E_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AIM2 absent in melanoma 2
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BLVRB biliverdin reductase B
BPIFA1 BPI fold containing family A, member 1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C5AR1 complement component 5a receptor 1
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CCL4 chemokine (C-C motif) ligand 4
CD14 CD14 molecule
CD163 CD163 molecule
CD84 CD84 molecule
CDC34 cell division cycle 34
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CES1 carboxylesterase 1
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CKAP4 cytoskeleton-associated protein 4
COG5 component of oligomeric golgi complex 5
COLEC12 collectin sub-family member 12
CPM carboxypeptidase M
CXCL13 chemokine (C-X-C motif) ligand 13
CYBB cytochrome b-245, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFS embryonal Fyn-associated substrate
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FXYD6 FXYD domain containing ion transport regulator 6
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GNLY granulysin
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KDM5B lysine (K)-specific demethylase 5B
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKNK1 MAP kinase interacting serine/threonine kinase 1
MOCOS molybdenum cofactor sulfurase
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG3 paternally expressed 3
PLD3 phospholipase D family, member 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PTN pleiotrophin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDF2L1 stromal cell-derived factor 2-like 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX11 SRY (sex determining region Y)-box 11
SQSTM1 sequestosome 1
TDO2 tryptophan 2,3-dioxygenase
TPBG trophoblast glycoprotein
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
TYROBP TYRO protein tyrosine kinase binding protein
USP3 ubiquitin specific peptidase 3
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
XYLT1 xylosyltransferase I
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTN1 actinin, alpha 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADD3 adducin 3 (gamma)
AK4 adenylate kinase 4
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDOA aldolase A, fructose-bisphosphate
ALDOB aldolase B, fructose-bisphosphate
ANXA3 annexin A3
APOA1 apolipoprotein A-I
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CBX3 chromobox homolog 3
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCNG1 cyclin G1
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPF centromere protein F, 350/400kDa
CFI complement factor I
CLTB clathrin, light chain B
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COASY CoA synthase
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSV cathepsin V
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
DPEP1 dipeptidase 1 (renal)
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM162A family with sequence similarity 162, member A
FAM171A1 family with sequence similarity 171, member A1
FBN1 fibrillin 1
FLNA filamin A, alpha
FST follistatin
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HADH hydroxyacyl-CoA dehydrogenase
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HN1L hematological and neurological expressed 1-like
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXA5 homeobox A5
HOXC6 homeobox C6
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KNG1 kininogen 1
L1CAM L1 cell adhesion molecule
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMCD1 LIM and cysteine-rich domains 1
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LTBP2 latent transforming growth factor beta binding protein 2
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MOK MOK protein kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NUAK1 NUAK family, SNF1-like kinase, 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDLIM2 PDZ and LIM domain 2 (mystique)
PEBP1 phosphatidylethanolamine binding protein 1
PGK1 phosphoglycerate kinase 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PLS3 plastin 3
PRSS23 protease, serine, 23
PWP1 PWP1 homolog (S. cerevisiae)
RPS11 ribosomal protein S11
RPS21 ribosomal protein S21
RUNX1 runt-related transcription factor 1
S100A10 S100 calcium binding protein A10
SEPT11 septin 11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFPQ splicing factor proline/glutamine-rich
SKP1 S-phase kinase-associated protein 1
SMC4 structural maintenance of chromosomes 4
SNRPG small nuclear ribonucleoprotein polypeptide G
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTAN1 spectrin, alpha, non-erythrocytic 1
STMN1 stathmin 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TPM1 tropomyosin 1 (alpha)
TRAM2 translocation associated membrane protein 2
UBE2N ubiquitin-conjugating enzyme E2N
VCAN versican
VCL vinculin
ZBTB18 zinc finger and BTB domain containing 18
Funding