BRD-K33272502_DG-041_HA1E_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K33272502_DG-041_HA1E_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BET1 Bet1 golgi vesicular membrane trafficking protein
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CANX calnexin
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
COG5 component of oligomeric golgi complex 5
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DERL2 derlin 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FPR1 formyl peptide receptor 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
GTPBP2 GTP binding protein 2
HAX1 HCLS1 associated protein X-1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
KLF4 Kruppel-like factor 4 (gut)
LRRC59 leucine rich repeat containing 59
LRRC8D leucine rich repeat containing 8 family, member D
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOCOS molybdenum cofactor sulfurase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER1 period circadian clock 1
PGM3 phosphoglucomutase 3
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RABGGTB Rab geranylgeranyltransferase, beta subunit
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEC61B Sec61 beta subunit
SERP1 stress-associated endoplasmic reticulum protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM39A transmembrane protein 39A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
ADA adenosine deaminase
AHNAK2 AHNAK nucleoprotein 2
ATF5 activating transcription factor 5
B3GNT1
BHLHE41 basic helix-loop-helix family, member e41
CASP6 caspase 6, apoptosis-related cysteine peptidase
CAST calpastatin
CCL8 chemokine (C-C motif) ligand 8
CCND1 cyclin D1
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CLEC2B C-type lectin domain family 2, member B
CLIC3 chloride intracellular channel 3
CTSZ cathepsin Z
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DUSP22 dual specificity phosphatase 22
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FBLN1 fibulin 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FZD7 frizzled class receptor 7
GTSE1 G-2 and S-phase expressed 1
H2AFY H2A histone family, member Y
HEG1 heart development protein with EGF-like domains 1
HMGB1 high mobility group box 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INTS8 integrator complex subunit 8
JADE2 jade family PHD finger 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MMP10 matrix metallopeptidase 10
MXRA5 matrix-remodelling associated 5
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PLK1 polo-like kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRSS23 protease, serine, 23
SDC1 syndecan 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPRR1A small proline-rich protein 1A
SYNPO synaptopodin
TGM2 transglutaminase 2
TPST2 tyrosylprotein sulfotransferase 2
WNT5A wingless-type MMTV integration site family, member 5A
ZCCHC24 zinc finger, CCHC domain containing 24
ZMYM3 zinc finger, MYM-type 3
Funding