BRD-K33272502_DG-041_SKM1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K33272502_DG-041_SKM1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AGR2 anterior gradient 2
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF5 activating transcription factor 5
BEX4 brain expressed, X-linked 4
CBS cystathionine-beta-synthase
CENPU centromere protein U
CLGN calmegin
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DPP4 dipeptidyl-peptidase 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GSN gelsolin
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
INPP1 inositol polyphosphate-1-phosphatase
JAK1 Janus kinase 1
KRT19 keratin 19, type I
LOC100505650 uncharacterized LOC100505650
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE8B phosphodiesterase 8B
PHGDH phosphoglycerate dehydrogenase
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
QPCT glutaminyl-peptide cyclotransferase
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
SARS seryl-tRNA synthetase
SCGB1D2 secretoglobin, family 1D, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST18 suppression of tumorigenicity 18, zinc finger
STK17B serine/threonine kinase 17b
SULF1 sulfatase 1
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TF transferrin
TMEM47 transmembrane protein 47
TPBG trophoblast glycoprotein
TRAF5 TNF receptor-associated factor 5
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
WDR7 WD repeat domain 7
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADCY3 adenylate cyclase 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRB2 adrenoceptor beta 2, surface
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CCDC85B coiled-coil domain containing 85B
CCL21 chemokine (C-C motif) ligand 21
CDC25B cell division cycle 25B
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHERP calcium homeostasis endoplasmic reticulum protein
EFNA1 ephrin-A1
EGR1 early growth response 1
EMP2 epithelial membrane protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
GSTP1 glutathione S-transferase pi 1
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HN1L hematological and neurological expressed 1-like
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LPL lipoprotein lipase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MRPL23 mitochondrial ribosomal protein L23
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUP98 nucleoporin 98kDa
PHYH phytanoyl-CoA 2-hydroxylase
PLAC8 placenta-specific 8
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PRKCD protein kinase C, delta
RPIA ribose 5-phosphate isomerase A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SLC43A3 solute carrier family 43, member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TSPAN8 tetraspanin 8
Funding