BRD-K33272502_DG-041_WSUDLCL2_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K33272502_DG-041_WSUDLCL2_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
C2 complement component 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCL4 chemokine (C-C motif) ligand 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DCTN3 dynactin 3 (p22)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMBT1 deleted in malignant brain tumors 1
EFS embryonal Fyn-associated substrate
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
FABP1 fatty acid binding protein 1, liver
FAM129A family with sequence similarity 129, member A
FYN FYN proto-oncogene, Src family tyrosine kinase
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGLJ3 immunoglobulin lambda joining 3
IL1R2 interleukin 1 receptor, type II
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2A integral membrane protein 2A
JUND jun D proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT7 keratin 7, type II
LMCD1 LIM and cysteine-rich domains 1
LXN latexin
MDFIC MyoD family inhibitor domain containing
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MT1X metallothionein 1X
MT2A metallothionein 2A
NFIB nuclear factor I/B
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDH9 protocadherin 9
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE1A phosphodiesterase 1A, calmodulin-dependent
PEG10 paternally expressed 10
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
POSTN periostin, osteoblast specific factor
PPIB peptidylprolyl isomerase B (cyclophilin B)
PROS1 protein S (alpha)
PTGDS prostaglandin D2 synthase 21kDa (brain)
QKI QKI, KH domain containing, RNA binding
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
S100B S100 calcium binding protein B
SAP30 Sin3A-associated protein, 30kDa
SARS seryl-tRNA synthetase
SCGB2A2 secretoglobin, family 2A, member 2
SELL selectin L
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SQRDL sulfide quinone reductase-like (yeast)
SRSF7 serine/arginine-rich splicing factor 7
TBPL1 TBP-like 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZMYND11 zinc finger, MYND-type containing 11
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
BAD BCL2-associated agonist of cell death
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CDC25A cell division cycle 25A
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CKB creatine kinase, brain
CLIC4 chloride intracellular channel 4
COG2 component of oligomeric golgi complex 2
DPYSL3 dihydropyrimidinase-like 3
DSE dermatan sulfate epimerase
ESR1 estrogen receptor 1
FHOD3 formin homology 2 domain containing 3
FSTL1 follistatin-like 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GSTM3 glutathione S-transferase mu 3 (brain)
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KLF10 Kruppel-like factor 10
LRRC15 leucine rich repeat containing 15
LTF lactotransferrin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MMP10 matrix metallopeptidase 10
NKX3-1 NK3 homeobox 1
PAEP progestagen-associated endometrial protein
PODXL podocalyxin-like
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX2 peroxiredoxin 2
PXDN peroxidasin
RBM38 RNA binding motif protein 38
S100A12 S100 calcium binding protein A12
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMC1A structural maintenance of chromosomes 1A
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF2 trefoil factor 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TUBB4B tubulin, beta 4B class IVb
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
Funding