| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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174 genes differentially expressed following the BRD-K33379087_tivantinib_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ADRB2 | adrenoceptor beta 2, surface |
| ASS1 | argininosuccinate synthase 1 |
| ATF3 | activating transcription factor 3 |
| BTG2 | BTG family, member 2 |
| CCND2 | cyclin D2 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CHIC2 | cysteine-rich hydrophobic domain 2 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 |
| COBL | cordon-bleu WH2 repeat protein |
| COPS7A | COP9 signalosome subunit 7A |
| CXCL13 | chemokine (C-X-C motif) ligand 13 |
| CYR61 | cysteine-rich, angiogenic inducer, 61 |
| DACH1 | dachshund family transcription factor 1 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa |
| DUSP14 | dual specificity phosphatase 14 |
| DUSP5 | dual specificity phosphatase 5 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 |
| EGR1 | early growth response 1 |
| EGR2 | early growth response 2 |
| EGR3 | early growth response 3 |
| ELANE | elastase, neutrophil expressed |
| ESR1 | estrogen receptor 1 |
| FAM46A | family with sequence similarity 46, member A |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B |
| FOSL1 | FOS-like antigen 1 |
| FOXD1 | forkhead box D1 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha |
| GADD45B | growth arrest and DNA-damage-inducible, beta |
| H2BFS | H2B histone family, member S (pseudogene) |
| HBEGF | heparin-binding EGF-like growth factor |
| HES1 | hes family bHLH transcription factor 1 |
| HIST1H1C | histone cluster 1, H1c |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2AE | histone cluster 1, H2ae |
| HIST1H2BD | histone cluster 1, H2bd |
| HIST1H2BE | histone cluster 1, H2be |
| HIST1H2BF | histone cluster 1, H2bf |
| HIST1H2BG | histone cluster 1, H2bg |
| HIST1H2BH | histone cluster 1, H2bh |
| HIST1H2BI | histone cluster 1, H2bi |
| HIST1H2BK | histone cluster 1, H2bk |
| HIST1H4H | histone cluster 1, H4h |
| HMOX1 | heme oxygenase 1 |
| IER3 | immediate early response 3 |
| IER5 | immediate early response 5 |
| JUN | jun proto-oncogene |
| KLF10 | Kruppel-like factor 10 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MAGEB2 | melanoma antigen family B2 |
| MCL1 | myeloid cell leukemia 1 |
| MIR22HG | MIR22 host gene |
| MMP9 | matrix metallopeptidase 9 |
| MT1E | metallothionein 1E |
| MT1M | metallothionein 1M |
| MT1X | metallothionein 1X |
| MTSS1 | metastasis suppressor 1 |
| NCAM1 | neural cell adhesion molecule 1 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| PDGFC | platelet derived growth factor C |
| PDLIM1 | PDZ and LIM domain 1 |
| PEG3 | paternally expressed 3 |
| PER2 | period circadian clock 2 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
| PLK2 | polo-like kinase 2 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A |
| PROM1 | prominin 1 |
| PTN | pleiotrophin |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) |
| RAP2B | RAP2B, member of RAS oncogene family |
| RPS11 | ribosomal protein S11 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 |
| SATB2 | SATB homeobox 2 |
| SESN1 | sestrin 1 |
| SFRP4 | secreted frizzled-related protein 4 |
| SIK3 | SIK family kinase 3 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 |
| SSX1 | synovial sarcoma, X breakpoint 1 |
| STAR | steroidogenic acute regulatory protein |
| TCF4 | transcription factor 4 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase |
| TMEM110 | transmembrane protein 110 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) |
| VAMP8 | vesicle-associated membrane protein 8 |
| VDAC1 | voltage-dependent anion channel 1 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing |
| ZCCHC2 | zinc finger, CCHC domain containing 2 |
| ZMAT3 | zinc finger, matrin-type 3 |
| Symbol | Name |
|---|---|
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
| ADD3 | adducin 3 (gamma) |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| AKR1C3 | aldo-keto reductase family 1, member C3 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 |
| ASPH | aspartate beta-hydroxylase |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 |
| BASP1 | brain abundant, membrane attached signal protein 1 |
| BIN1 | bridging integrator 1 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 |
| CAV1 | caveolin 1, caveolae protein, 22kDa |
| CCND1 | cyclin D1 |
| CD59 | CD59 molecule, complement regulatory protein |
| CDK1 | cyclin-dependent kinase 1 |
| CEMIP | cell migration inducing protein, hyaluronan binding |
| COL1A2 | collagen, type I, alpha 2 |
| COL3A1 | collagen, type III, alpha 1 |
| COL4A1 | collagen, type IV, alpha 1 |
| COL4A2 | collagen, type IV, alpha 2 |
| COL5A2 | collagen, type V, alpha 2 |
| COL6A1 | collagen, type VI, alpha 1 |
| COL6A3 | collagen, type VI, alpha 3 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| FCGRT | Fc fragment of IgG, receptor, transporter, alpha |
| FSTL1 | follistatin-like 1 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
| HLA-B | major histocompatibility complex, class I, B |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha |
| HMGA2 | high mobility group AT-hook 2 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) |
| IFNGR1 | interferon gamma receptor 1 |
| IFRD2 | interferon-related developmental regulator 2 |
| IGFBP4 | insulin-like growth factor binding protein 4 |
| KIAA0101 | KIAA0101 |
| KIF11 | kinesin family member 11 |
| L1CAM | L1 cell adhesion molecule |
| LPAR1 | lysophosphatidic acid receptor 1 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) |
| MAP2K6 | mitogen-activated protein kinase kinase 6 |
| MARCKSL1 | MARCKS-like 1 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 |
| NUSAP1 | nucleolar and spindle associated protein 1 |
| PBK | PDZ binding kinase |
| PGM1 | phosphoglucomutase 1 |
| PLP1 | proteolipid protein 1 |
| PNMA2 | paraneoplastic Ma antigen 2 |
| QDPR | quinoid dihydropteridine reductase |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| RGS5 | regulator of G-protein signaling 5 |
| S100A7 | S100 calcium binding protein A7 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| SOX11 | SRY (sex determining region Y)-box 11 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) |
| TBC1D16 | TBC1 domain family, member 16 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 |
| TFAP2B | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) |
| TFPI2 | tissue factor pathway inhibitor 2 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TSPAN6 | tetraspanin 6 |
| TUBB2B | tubulin, beta 2B class IIb |
| UBE2A | ubiquitin-conjugating enzyme E2A |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
| WNT5A | wingless-type MMTV integration site family, member 5A |
| WWTR1 | WW domain containing transcription regulator 1 |
| ZNF395 | zinc finger protein 395 |
| ZNF589 | zinc finger protein 589 |
