BRD-K33379087_tivantinib_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K33379087_tivantinib_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTN1 actinin, alpha 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AURKA aurora kinase A
CCNB1 cyclin B1
CD14 CD14 molecule
CD24 CD24 molecule
CDC20 cell division cycle 20
CPB1 carboxypeptidase B1 (tissue)
CXCL3 chemokine (C-X-C motif) ligand 3
DOCK4 dedicator of cytokinesis 4
EDN1 endothelin 1
EMP3 epithelial membrane protein 3
FGFR3 fibroblast growth factor receptor 3
FOS FBJ murine osteosarcoma viral oncogene homolog
GLIPR1 GLI pathogenesis-related 1
GRWD1 glutamate-rich WD repeat containing 1
H2BFS H2B histone family, member S (pseudogene)
HACD1 3-hydroxyacyl-CoA dehydratase 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
KRT7 keratin 7, type II
KYNU kynureninase
MRPS30 mitochondrial ribosomal protein S30
MSLN mesothelin
MSRA methionine sulfoxide reductase A
PGC progastricsin (pepsinogen C)
PLK2 polo-like kinase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
UBE2S ubiquitin-conjugating enzyme E2S

decreased expression

Symbol Name
AIM1 absent in melanoma 1
APOD apolipoprotein D
BAG3 BCL2-associated athanogene 3
CCNE2 cyclin E2
CDK1 cyclin-dependent kinase 1
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
DCN decorin
DPP4 dipeptidyl-peptidase 4
ETV1 ets variant 1
FBLN1 fibulin 1
G0S2 G0/G1 switch 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
MALL mal, T-cell differentiation protein-like
MGLL monoglyceride lipase
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MYO6 myosin VI
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PPAP2B phosphatidic acid phosphatase type 2B
RGS17 regulator of G-protein signaling 17
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNX7 sorting nexin 7
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
Funding