BRD-K33680967_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K33680967_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
CD59 CD59 molecule, complement regulatory protein
CDA cytidine deaminase
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
DSP desmoplakin
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
G0S2 G0/G1 switch 2
GPC3 glypican 3
GYPC glycophorin C (Gerbich blood group)
H1F0 H1 histone family, member 0
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LIF leukemia inhibitory factor
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MPZL2 myelin protein zero-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
RAD23A RAD23 homolog A (S. cerevisiae)
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
S100A11 S100 calcium binding protein A11
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPRR1B small proline-rich protein 1B
THBD thrombomodulin
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TXNIP thioredoxin interacting protein
WDR1 WD repeat domain 1
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CPB1 carboxypeptidase B1 (tissue)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DPYSL2 dihydropyrimidinase-like 2
DUSP22 dual specificity phosphatase 22
EIF5 eukaryotic translation initiation factor 5
FASTKD5 FAST kinase domains 5
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8H golgin A8 family, member H
GPM6B glycoprotein M6B
HMGN3 high mobility group nucleosomal binding domain 3
HSPA1A heat shock 70kDa protein 1A
IL17RB interleukin 17 receptor B
LGALS1 lectin, galactoside-binding, soluble, 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LUC7L3 LUC7-like 3 (S. cerevisiae)
LUM lumican
MAGED1 melanoma antigen family D1
METTL3 methyltransferase like 3
MKKS McKusick-Kaufman syndrome
MMD monocyte to macrophage differentiation-associated
MTMR4 myotubularin related protein 4
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PARP2 poly (ADP-ribose) polymerase 2
PBX3 pre-B-cell leukemia homeobox 3
PDGFC platelet derived growth factor C
PMP22 peripheral myelin protein 22
PNMA2 paraneoplastic Ma antigen 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPF4B pre-mRNA processing factor 4B
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TOM1L1 target of myb1 (chicken)-like 1
TSPAN12 tetraspanin 12
TUBB6 tubulin, beta 6 class V
ZIC1 Zic family member 1
Funding