BRD-K34092011_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K34092011_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL1 adhesion G protein-coupled receptor L1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CCDC53 coiled-coil domain containing 53
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP2 cellular retinoic acid binding protein 2
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
EFHC1 EF-hand domain (C-terminal) containing 1
EIF5A eukaryotic translation initiation factor 5A
F12 coagulation factor XII (Hageman factor)
GLRX glutaredoxin (thioltransferase)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HOXC6 homeobox C6
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
LXN latexin
MLF1 myeloid leukemia factor 1
MTSS1 metastasis suppressor 1
NMU neuromedin U
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCOLCE procollagen C-endopeptidase enhancer
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PNPLA4 patatin-like phospholipase domain containing 4
PRAF2 PRA1 domain family, member 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RAB13 RAB13, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS10 regulator of G-protein signaling 10
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6

decreased expression

Symbol Name
AGR2 anterior gradient 2
ATP9A ATPase, class II, type 9A
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CNPY3 canopy FGF signaling regulator 3
COL10A1 collagen, type X, alpha 1
DAPK1 death-associated protein kinase 1
DUSP3 dual specificity phosphatase 3
EIF3B eukaryotic translation initiation factor 3, subunit B
FADD Fas (TNFRSF6)-associated via death domain
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
HBEGF heparin-binding EGF-like growth factor
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MRPS2 mitochondrial ribosomal protein S2
MX2 MX dynamin-like GTPase 2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NUDCD3 NudC domain containing 3
PDGFA platelet-derived growth factor alpha polypeptide
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RRBP1 ribosome binding protein 1
SAC3D1 SAC3 domain containing 1
SATB1 SATB homeobox 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TACC1 transforming, acidic coiled-coil containing protein 1
Funding