BRD-K34363599_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K34363599_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADGRG6 adhesion G protein-coupled receptor G6
AMOTL2 angiomotin like 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
CALML5 calmodulin-like 5
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN3 claudin 3
CRABP2 cellular retinoic acid binding protein 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GREB1 growth regulation by estrogen in breast cancer 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMGB2 high mobility group box 2
IL1R2 interleukin 1 receptor, type II
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLK5 kallikrein-related peptidase 5
KYNU kynureninase
LCN2 lipocalin 2
MTDH metadherin
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYRF myelin regulatory factor
NFIL3 nuclear factor, interleukin 3 regulated
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PKP4 plakophilin 4
PSAT1 phosphoserine aminotransferase 1
QPCT glutaminyl-peptide cyclotransferase
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
YARS tyrosyl-tRNA synthetase
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
ADA adenosine deaminase
ADIRF adipogenesis regulatory factor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
B3GNT1
C8ORF4 chromosome 8 open reading frame 4
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CP ceruloplasmin (ferroxidase)
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EGR2 early growth response 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
GPNMB glycoprotein (transmembrane) nmb
GRWD1 glutamate-rich WD repeat containing 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1C1 mannosidase, alpha, class 1C, member 1
MAT2A methionine adenosyltransferase II, alpha
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
NRN1 neuritin 1
PLS3 plastin 3
PLTP phospholipid transfer protein
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
RGS4 regulator of G-protein signaling 4
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB1 SATB homeobox 1
SEPW1 selenoprotein W, 1
SFRP4 secreted frizzled-related protein 4
SYBU syntabulin (syntaxin-interacting)
TARDBP TAR DNA binding protein
TSPAN7 tetraspanin 7
WFS1 Wolfram syndrome 1 (wolframin)
Funding