BRD-K34968258_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K34968258_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRF5 adhesion G protein-coupled receptor F5
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
CD9 CD9 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CTGF connective tissue growth factor
DLC1 DLC1 Rho GTPase activating protein
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGR1 early growth response 1
EGR3 early growth response 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELN elastin
EMP1 epithelial membrane protein 1
EREG epiregulin
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP7 fatty acid binding protein 7, brain
FAM131A family with sequence similarity 131, member A
FBLN2 fibulin 2
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IER3 immediate early response 3
IL6 interleukin 6
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JAG1 jagged 1
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LPP LIM domain containing preferred translocation partner in lipoma
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCAM melanoma cell adhesion molecule
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MECOM MDS1 and EVI1 complex locus
MPZL2 myelin protein zero-like 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NOTCH1 notch 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDE4B phosphodiesterase 4B, cAMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PLBD1 phospholipase B domain containing 1
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RAP1GAP2 RAP1 GTPase activating protein 2
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQSTM1 sequestosome 1
TACC2 transforming, acidic coiled-coil containing protein 2
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
UPP1 uridine phosphorylase 1
VWF von Willebrand factor
WISP2 WNT1 inducible signaling pathway protein 2
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
C5ORF30 chromosome 5 open reading frame 30
C6ORF62 chromosome 6 open reading frame 62
CCNF cyclin F
CDKN3 cyclin-dependent kinase inhibitor 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CSAD cysteine sulfinic acid decarboxylase
DAPK1 death-associated protein kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EPHA3 EPH receptor A3
FAM111A family with sequence similarity 111, member A
FAM198B family with sequence similarity 198, member B
FASTKD5 FAST kinase domains 5
FUBP1 far upstream element (FUSE) binding protein 1
FYB FYN binding protein
GPER1 G protein-coupled estrogen receptor 1
HSPA1A heat shock 70kDa protein 1A
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIAA0907 KIAA0907
KIF20A kinesin family member 20A
LAMP1 lysosomal-associated membrane protein 1
LBH limb bud and heart development
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LONP2 lon peptidase 2, peroxisomal
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL3 methyltransferase like 3
MLPH melanophilin
MSH6 mutS homolog 6
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCA protein kinase C, alpha
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PXMP2 peroxisomal membrane protein 2, 22kDa
RNASET2 ribonuclease T2
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RSRP1 arginine/serine-rich protein 1
RTN3 reticulon 3
RXRA retinoid X receptor, alpha
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF1 serine/arginine-rich splicing factor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TMED2 transmembrane emp24 domain trafficking protein 2
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
WT1 Wilms tumor 1
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF586 zinc finger protein 586
Funding